Effects of unilateral temporal lobe resections on the cerebral processing of emotionally negative visual stimuli

单侧颞叶切除对情绪负性视觉刺激的大脑处理的影响

• 批准号: 317013141
• 负责人: Professor Dr. Christian G. Bien
• 金额: --
• 依托单位: Arbeitseinheit 02 - Affektive Neuropsychologie (Allg. Psychologie II)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/317013141?language=en
• 关键词: Effects; unilateral; temporal; lobe; resections

This project investigates effects of unilateral temporal lobe resections on the perception of and memory for visually presented emotionally negative and neutral pictures, faces, and words. Resections comprise either amygdala, hippocampus, and surrounding structures (AH+) or the amygdala and parts of the anterior temporal lobe, sparing the hippocampus (AAT+). Electrophysiologically, we investigate the extent to which such resections 1) reduce emotion-sensitive event-related potentials (ERPs) of the EEG. 2) Such reductions are hemisphere-specific or specific to certain stimulus types. 3) Differences exist between the AH+ and AAT+ groups. In parallel, using functional magnetic resonance imaging (fMRI), we test for 4) changes in hemodynamic responses during perception of and memory for emotional stimuli following temporal lobe resections. 5) Investigate whether any effects are stimulus- or hemisphere-specific. 6) AH+ and AAT+ groups differ in their activation patterns. Together, results will provide causal evidence regarding the role of amygdala and surrounding structures in affective stimulus processing.

该项目研究单侧颞叶切除对视觉呈现的情绪消极和中性图片、面孔和文字的感知和记忆的影响。切除包括杏仁核、海马和周围结构 (AH+) 或杏仁核和部分前颞叶，保留海马 (AAT+)。从电生理学角度，我们研究了这种切除1）降低脑电图情绪敏感事件相关电位（ERP）的程度。 2) 这种减少是半球特异性的或特定于某些刺激类型的。 3) AH+和AAT+组之间存在差异。与此同时，我们使用功能磁共振成像 (fMRI) 测试了颞叶切除后情绪刺激的感知和记忆过程中血流动力学反应的变化。 5) 研究是否存在刺激或半球特异性的影响。 6) AH+和AAT+组的激活模式不同。总之，结果将提供有关杏仁核及其周围结构在情感刺激处理中的作用的因果证据。