Effects of unilateral temporal lobe resections on the cerebral processing of emotionally negative visual stimuli

这个项目调查了单侧颞叶切除对视觉呈现的情绪消极和中性的图片、面孔和单词的知觉和记忆的影响。切除部分包括杏仁核、海马体及其周围结构(AH+)或杏仁核和部分前颞叶，而不包括海马体(AAT+)。在电生理学方面，我们调查了这种切除在多大程度上降低了EEG的情绪敏感事件相关电位(ERPs)。2)这种减少是特定于半球的或特定于某些刺激类型的。3)AH+组和AAT+组之间存在差异。同时，使用功能磁共振成像(FMRI)，我们测试4)在对情绪刺激的感知和记忆过程中，在颞叶切除后的血流动力学反应的变化。5)调查是否有刺激或大脑半球特有的影响。6)AH+和AAT+组的激活模式不同。总之，这些结果将为杏仁核及其周围结构在情感刺激处理中的作用提供因果证据。

This project investigates effects of unilateral temporal lobe resections on the perception of and memory for visually presented emotionally negative and neutral pictures, faces, and words. Resections comprise either amygdala, hippocampus, and surrounding structures (AH+) or the amygdala and parts of the anterior temporal lobe, sparing the hippocampus (AAT+). Electrophysiologically, we investigate the extent to which such resections 1) reduce emotion-sensitive event-related potentials (ERPs) of the EEG. 2) Such reductions are hemisphere-specific or specific to certain stimulus types. 3) Differences exist between the AH+ and AAT+ groups. In parallel, using functional magnetic resonance imaging (fMRI), we test for 4) changes in hemodynamic responses during perception of and memory for emotional stimuli following temporal lobe resections. 5) Investigate whether any effects are stimulus- or hemisphere-specific. 6) AH+ and AAT+ groups differ in their activation patterns. Together, results will provide causal evidence regarding the role of amygdala and surrounding structures in affective stimulus processing.