Sensing and signaling integration in the surveillance mechanisms of the spindle position checkpoint (21)

主轴位置检查点监视机制中的传感和信号集成 (21)

• 批准号: 317827090
• 金额: --
• 依托单位: Centre for Organismal Studies (COS)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/317827090?language=en
• 关键词: Sensing; signaling; integration; surveillance; mechanisms

Gislene Pereira (TP21) explores how the spindle position checkpoint (SPOC) senses mis-oriented spindles. The group will follow the hypothesis that the protein kinase Kin4 changes its localization as part of the sensory mechanism that recognizes errors in spindle positioning. In collaboration with Knop (TP10) and Ruppert (Z1), the group will determine how Kin4 changes its localization upon stresses that induce microtubule defects, among others, and the role of cell polarity components in this process.

Gislene佩雷拉（TP 21）探讨了纺锤体位置检查点（SPOC）如何感知错误取向的纺锤体。该小组将遵循这样的假设，即蛋白激酶Kin4改变其定位，作为识别纺锤体定位错误的感觉机制的一部分。与Knop（TP10）和Ruppert（Z1）合作，该小组将确定Kin4如何在诱导微管缺陷的应力下改变其定位，以及细胞极性成分在此过程中的作用。