Cell-type specific mitochondrial Ca2+ handling and selective vulnerability to mitochondrial dysfunction in different dopaminergic neuron populations (B07)

不同多巴胺能神经元群体中细胞类型特异性线粒体 Ca2 处理和对线粒体功能障碍的选择性脆弱性 (B07)

• 批准号: 318035143
• 金额: --
• 依托单位: Institut für Zoologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/318035143?language=en
• 关键词: Cell; type; specific; mitochondrial; Ca2+

We aim to understand if and how the different, neuron type specific dependence on mitochondrial Ca2+ handling might contribute to the selective vulnerability of certain neuron types to mitochondrial dysfunction. We will a) analyse how mitochondria contribute to controlling free cytosolic Ca2+ in dopaminergic midbrain neurons of the substantia nigra (SN) vs. the ventral tegmental area (VTA) and b) if cell-type specific differences in mitochondrial Ca2+ handling between these two neuron types might contribute to their differential susceptibility to neurodegeneration caused by mitochondrial dysfunction, as seen in ageing and Parkinson¿s disease.

我们的目的是了解不同的，神经元类型的线粒体Ca2+处理的特定依赖性是否以及如何可能有助于某些神经元类型的线粒体功能障碍的选择性脆弱性。我们将a）分析线粒体如何有助于控制黑质（SN）与腹侧被盖区（VTA）多巴胺能中脑神经元中的游离胞质Ca 2+，以及B）这两种神经元类型之间线粒体Ca 2+处理的细胞类型特异性差异是否可能有助于其对线粒体功能障碍引起的神经变性的不同易感性，如在衰老和帕金森病中所见。