Regulation of neural excitability and neural-network function in resilience - a multimodal and (back-) translational approach (B05)

B05将利用经颅磁刺激人脑背内侧前额叶皮层（作为探针）结合同步脑电图（作为读数），确定该皮层区域的兴奋性和皮质-皮质功能连通性，并探索不同恐惧条件和兴奋性变化期间的适应性应激反应与不同功能皮质连通性特征和弹性结果相关的假设。在小鼠和人类中，B5将进行最先进的功能连接测量，并将人类刺激激活范式反向翻译到小鼠中。最后，将开发因果光遗传操作。

Using neuronavigated transcranial magnetic stimulation over human dorsomedial prefrontal cortex (as a probe) in combination with simultaneous EEG (as a read-out), B05 will determine the excitability and cortico-cortical functional connectivity of this cortex area, pursuing the hypothesis that adaptive stress response during differential fear conditioning and excitability changes are linked to distinct functional cortical connectivity signatures and resilient outcome. Both, in mice and humans, B5 will conduct state-of-the-art functional connectivity measures, and a back-translation of human stimulus activation paradigms to the mouse. Finally, causal optogenetic manipulations will be developed.