Structure, function, and dynamics of SLC26 and NCS2 transporters (P23*)

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Members of the SLC26 and NCS2 families of secondary transporters are ubiquitously expressed in all kingdoms of life. Human representatives of these families perform critical roles and their malfunctioning is associated with diseases. Recent structures revealed that both families share an identical and novel fold composed of two inverted repeats of seven transmembrane segments. How the transport of water-soluble substrates is facilitated by this fold is unknown. We will study structural, functional and dynamic aspects in both families and highlight how versatile the general design principles of this fold are.