Development of culture method for three-dimensional cardiac tissue derived from induced pluripotent stem cell using rotating wall vessel bioreactor

利用旋转壁血管生物反应器开发诱导多能干细胞三维心脏组织培养方法

• 批准号: 19K18179
• 负责人: Nakazato Taro
• 金额: $ 2.66万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K18179/
• 关键词: iPS; 組織工学; 回転浮遊培養; 心不全; iPS細胞; Myosin heavy chain 7; Connexin 43; 3次元心筋組織

项目成果

Functional engineered heart tissue cultured in a rotating wall vessel bioreactor improve cardiac function in the distressed rat heart

在旋转壁血管生物反应器中培养的功能性工程心脏组织可改善受损大鼠心脏的心脏功能

• 发表时间: 2020
• 作者: Taro Nakazato;Shigeru Miyagawa;Toshimasa Uemura;Li Liu;Junjun Li;Masao Sasai;Akima Harada;Takayoshi Ueno;Koichi Toda;Toru Kuratani;Yoshiki Sawa
• 通讯作者: Yoshiki Sawa

Dynamic tissue culture in a rotating wall vessel bioreactor yields functional engineered cardiac constructs derived from induced pluripotent stem cells via activated mTOR-related signaling pathway

旋转壁血管生物反应器中的动态组织培养通过激活的 mTOR 相关信号通路产生源自诱导多能干细胞的功能性工程心脏结构

• 发表时间: 2020
• 作者: Taro Nakazato;Shigeru Miyagawa;Toshimasa Uemura;Li Liu;Junjun Li;Masao Sasai;Akima Harada;Takayoshi Ueno;Koichi Toda;Toru Kuratani;Yoshiki Sawa
• 通讯作者: Yoshiki Sawa

Engineered three-dimensional cardiac tissues maturated by dynamic culture in a rotating wall vessel bioreactor remodel the diseased heart in the rat infarction model

通过在旋转壁血管生物反应器中动态培养而成熟的工程三维心脏组织重塑了大鼠梗塞模型中的患病心脏

• 发表时间: 2020
• 作者: Taro Nakazato;Shigeru Miyagawa;Toshimasa Uemura;Li Liu;Junjun Li;Masao Sasai;Akima Harada;Takayoshi Ueno;Koichi Toda;Toru Kuratani;Yoshiki Sawa
• 通讯作者: Yoshiki Sawa