Suppression of radiation-induced gastrointestinal disorders through the regulation of intestinal flora by the tumor suppressor p53

通过肿瘤抑制因子 p53 调节肠道菌群来抑制辐射引起的胃肠道疾病

• 批准号: 19K22525
• 负责人: TANIKAWA CHIZU
• 金额: $ 4.16万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Research (Exploratory)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-06-28 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K22525/
• 关键词: p53; 腸内細菌叢; 消化管障害; microbiome

项目成果

Identification of Novel Loci and New Risk Variant in Known Loci for Colorectal Cancer Risk in East Asians.

• DOI: 10.1158/1055-9965.epi-19-0755
• 发表时间: 2020-03
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Lu Y;Kweon SS;Cai Q;Tanikawa C;Shu XO;Jia WH;Xiang YB;Huyghe JR;Harrison TA;Kim J;Shin A;Kim DH;Matsuo K;Jee SH;Guo X;Wen W;Shi J;Li B;Wang N;Shin MH;Li HL;Ren Z;Oh JH;Oze I;Ahn YO;Jung KJ;Gao J;Gao YT;Pan ZZ;Kamatani Y;Chan AT;Gsur A;Hampe J;Le Marchand L;Li L;Lindblom A;Moreno V;Newcomb PA;Offit K;Pharoah PDP;van Duijnhoven FJB;Van Guelpen B;Vodicka P;Weinstein SJ;Wolk A;Wu AH;Hsu L;Zeng YX;Long J;Peters U;Matsuda K;Zheng W
• 通讯作者: Zheng W

Genetic variants of calcium and vitamin D metabolism in kidney stone disease

肾结石疾病中钙和维生素 D 代谢的遗传变异

• DOI: 10.1101/515882
• 发表时间: 2019
• 作者: Howles S

Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease

• DOI: 10.1172/jci127750
• 发表时间: 2020-04-01
• 期刊: JOURNAL OF CLINICAL INVESTIGATION
• 影响因子: 15.9
• 作者: Curry，Joshua N.;Saurette，Matthew;Yu，Alan S. L.
• 通讯作者: Yu，Alan S. L.

A Polymorphic Variant in p19Arf Confers Resistance to Chemically Induced Skin Tumors by Activating the p53 Pathway

p19Arf 的多态性变体通过激活 p53 途径赋予对化学诱导的皮肤肿瘤的抵抗力

• DOI: 10.1016/j.jid.2018.12.027
• 发表时间: 2019
• 期刊: Journal of Investigative Dermatology
• 影响因子: 6.5
• 作者: Saito M;Okumura K;Isogai E;Araki K;Tanikawa C;Matsuda K;Kamijo T;Kominami R;Wakabayashi Y.
• 通讯作者: Wakabayashi Y.

Identification of a novel uterine leiomyoma GWAS locus in a Japanese population

• DOI: 10.1038/s41598-020-58066-8
• 发表时间: 2020-01-27
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Sakai, Kensuke;Tanikawa, Chizu;Matsuda, Koichi
• 通讯作者: Matsuda, Koichi