Identification of functional variants by comprehensive analysis of coding variants for the implementation of genomic medicine

通过综合分析编码变异来鉴定功能变异，以实施基因组医学

• 批准号: 19H03881
• 负责人: TANIKAWA CHIZU
• 金额: $ 11.15万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19H03881/
• 关键词: SNP; ゲノム医療

项目成果

Identification of Novel Loci and New Risk Variant in Known Loci for Colorectal Cancer Risk in East Asians.

• DOI: 10.1158/1055-9965.epi-19-0755
• 发表时间: 2020-03
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Lu Y;Kweon SS;Cai Q;Tanikawa C;Shu XO;Jia WH;Xiang YB;Huyghe JR;Harrison TA;Kim J;Shin A;Kim DH;Matsuo K;Jee SH;Guo X;Wen W;Shi J;Li B;Wang N;Shin MH;Li HL;Ren Z;Oh JH;Oze I;Ahn YO;Jung KJ;Gao J;Gao YT;Pan ZZ;Kamatani Y;Chan AT;Gsur A;Hampe J;Le Marchand L;Li L;Lindblom A;Moreno V;Newcomb PA;Offit K;Pharoah PDP;van Duijnhoven FJB;Van Guelpen B;Vodicka P;Weinstein SJ;Wolk A;Wu AH;Hsu L;Zeng YX;Long J;Peters U;Matsuda K;Zheng W
• 通讯作者: Zheng W

Genetic susceptibility to hepatocellular carcinoma in chromosome 22q13.31, findings of a genome-wide association study.

• DOI: 10.1002/jgh3.12682
• 发表时间: 2021-12
• 期刊: JGH open : an open access journal of gastroenterology and hepatology
• 作者: Wang Z;Budhu AS;Shen Y;Wong LL;Hernandez BY;Tiirikainen M;Ma X;Irwin ML;Lu L;Zhao H;Lim JK;Taddei T;Mishra L;Pawlish K;Stroup A;Brown R;Nguyen MH;Koshiol J;Hernandez MO;Forgues M;Yang HI;Lee MH;Huang YH;Iwasaki M;Goto A;Suzuki S;Matsuda K;Tanikawa C;Kamatani Y;Mann D;Guarnera M;Shetty K;Thomas CE;Yuan JM;Khor CC;Koh WP;Risch H;Wang XW;Yu H
• 通讯作者: Yu H

Genetic variants of calcium and vitamin D metabolism in kidney stone disease

肾结石疾病中钙和维生素 D 代谢的遗传变异

• DOI: 10.1101/515882
• 发表时间: 2019
• 作者: Howles S

Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease

• DOI: 10.1172/jci127750
• 发表时间: 2020-04-01
• 期刊: JOURNAL OF CLINICAL INVESTIGATION
• 影响因子: 15.9
• 作者: Curry，Joshua N.;Saurette，Matthew;Yu，Alan S. L.
• 通讯作者: Yu，Alan S. L.

A Polymorphic Variant in p19Arf Confers Resistance to Chemically Induced Skin Tumors by Activating the p53 Pathway

p19Arf 的多态性变体通过激活 p53 途径赋予对化学诱导的皮肤肿瘤的抵抗力

• DOI: 10.1016/j.jid.2018.12.027
• 发表时间: 2019
• 期刊: Journal of Investigative Dermatology
• 影响因子: 6.5
• 作者: Saito M;Okumura K;Isogai E;Araki K;Tanikawa C;Matsuda K;Kamijo T;Kominami R;Wakabayashi Y.
• 通讯作者: Wakabayashi Y.