Myostatin-induced mechanisms of inflammatory bone and cartilage destruction by invasive fibroblast-like synoviocytes (A11*)

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To investigate the role of myostatin in inflammatory destruction of tissue barriers, we will compare the effects of myostatin deficiency and phamacological inhibition on joint destruction in three arthritis models (different TNF-dependent). In addition, fibroblast-specific myostatin and activin wil be investigated by using Col1α2-Cre mice. Moreover, we want to evaluate the involvement of myostatin/ activin-mediated Smad2 signaling on synovial fibroblast-mediated matrix degradation by investigating proliferation, migration, apoptosis, invasive capacity, adhesion molecules, matrix-degrading proteases as well as involved signaling pathways.