神経突起・神経炎症イメージングによるパーキンソン病の病態解明

通过神经突和神经炎症成像阐明帕金森病的病理学

• 批准号: 20F20113
• 负责人: 鎌形 康司
• 金额: $ 1.47万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-24 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20F20113/
• 关键词: Parkinson's disease; Diffusion MRI; Free water imaging; Neurite imaging; Fixel-based analysis; Parkinson’s disease; Tremor dominant; Diffusion tensor imaging; Free-water imaging; Neurall plasticity; Neuroinflammation

This research applied neurite orientation dispersion and density imaging, free-water imaging, and fixel-based analysis to baseline and follow-up data of subjects with Parkinson's disease (PD). As results of cross-sectional studies, we showed different patterns of brain tissue microstructural changes (i.e., neuronal loss and neuroinflammation) in different clinical subtypes of PD (i.e., with vs. without neurocognitive and psychiatric symptoms, tremor dominant vs. postural instability and gait disorder motor subtypes, with vs. without mild cognitive impairment, and with vs. without glucocerebrosidase gene mutations). Furthermore, in a longitudinal analysis, we demonstrated white matter neural compensation among PD patients with normal cognition one year after diagnosis.

本研究应用神经突方向弥散和密度成像、自由水成像和基于固定的分析对帕金森病（PD）受试者的基线和随访数据进行分析。作为横断面研究的结果，我们显示了不同模式的脑组织微结构变化（即，神经元损失和神经炎症）在PD的不同临床亚型中（即，具有与不具有神经认知和精神症状、震颤显性与姿势不稳定和步态障碍运动亚型、具有与不具有轻度认知损害、以及具有与不具有葡糖脑苷脂酶基因突变）。此外，在纵向分析中，我们证明了白色神经补偿与认知正常的PD患者诊断后一年。

项目成果

MRF & synthetic MRI of the brain: what is it good for?

磁流变法

• 发表时间: 2021
• 作者: Christina Andica;Koji Kamagata;Masahiro Abe;Wataru Uchida;Yuya Saito;Hayato Nozaki;Kaito Takabayashi;Masaaki Hori;Shigeki Aoki;Christina Andica
• 通讯作者: Christina Andica

Microstructural white matter abnormalities in multiple sclerosis and neuromyelitis optica spectrum disorders: Evaluation by advanced diffusion imaging

• DOI: 10.1016/j.jns.2022.120205
• 发表时间: 2022-03-05
• 期刊: JOURNAL OF THE NEUROLOGICAL SCIENCES
• 影响因子: 4.4
• 作者: Kato, Shimpei;Hagiwara, Akifumi;Aoki, Shigeki
• 通讯作者: Aoki, Shigeki

Effect of hybrid of compressed sensing and parallel imaging on the quantitative values measured by 3D quantitative synthetic MRI: A phantom study

压缩感知和并行成像混合对 3D 定量合成 MRI 测量的定量值的影响：一项模型研究

• DOI: 10.1016/j.mri.2021.01.001
• 发表时间: 2021
• 期刊: Magnetic Resonance Imaging
• 影响因子: 2.5
• 作者: Murata Syo;Hagiwara Akifumi;Fujita Shohei;Haruyama Takuya;Kato Shimpei;Andica Christina;Kamagata Koji;Goto Masami;Hori Masaaki;Yoneyama Masami;Hamasaki Nozomi;Hoshito Haruyoshi;Aoki Shigeki
• 通讯作者: Aoki Shigeki

White Matter Plasticity in Newly Diagnosed Parkinson’s Disease With/Without Mild Cognitive Impairment

新诊断帕金森病伴/不伴轻度认知障碍的白质可塑性

• 发表时间: 2020
• 作者: Christina Andica;Koji Kamagata;Yuya Saito;Wataru Uchida;Akifumi Hagiwara;Shohei Fujita;Syo Murata;Masaaki Hori;and Shigeki Aoki
• 通讯作者: and Shigeki Aoki

Corticospinal Tracts Neuroplasticity in Drug-Naive Newly Diagnosed Parkinson's Disease: A Fixel-Based Analysis.

未接受药物治疗的新诊断帕金森病的皮质脊髓束神经可塑性：基于 Fixel 的分析。

• 发表时间: 2020
• 作者: Christina Andica;Koji Kamagata;Yuya Saito;Wataru Uchida;Shigeki Aoki.
• 通讯作者: Shigeki Aoki.