神経突起・神経炎症イメージングによるパーキンソン病の病態解明

本研究应用神经突定向分散和密度成像、自由水成像和基于固定物的分析对帕金森病（PD）受试者的基线和随访数据进行分析。作为横断面研究的结果，我们显示了不同临床亚型PD（即有无神经认知和精神症状，震颤显性与姿势不稳定和步态障碍运动亚型，有无轻度认知障碍，有无糖脑苷酶基因突变）中不同模式的脑组织微结构变化（即神经元丢失和神经炎症）。此外，在一项纵向分析中，我们证实了PD患者在诊断一年后认知正常的白质神经代偿。

This research applied neurite orientation dispersion and density imaging, free-water imaging, and fixel-based analysis to baseline and follow-up data of subjects with Parkinson's disease (PD). As results of cross-sectional studies, we showed different patterns of brain tissue microstructural changes (i.e., neuronal loss and neuroinflammation) in different clinical subtypes of PD (i.e., with vs. without neurocognitive and psychiatric symptoms, tremor dominant vs. postural instability and gait disorder motor subtypes, with vs. without mild cognitive impairment, and with vs. without glucocerebrosidase gene mutations). Furthermore, in a longitudinal analysis, we demonstrated white matter neural compensation among PD patients with normal cognition one year after diagnosis.