Synthesis ans Characterisation of Redox-active Dendrimers with patterned Periphery and Recognition Function for 2D and 3 D Materials. Construction kit with variable building blocks.

具有图案化外围和 2D 和 3D 材料识别功能的氧化还原活性树枝状聚合物的合成和表征。

• 批准号: 322638067
• 负责人: Professorin Dr. Carmen-Simona Jordan, Ph.D.
• 金额: --
• 依托单位: Professur für Maschinenbau, insbesondere chemische Prozesstechnik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/322638067?language=en
• 关键词: Synthesis; ans; Characterisation; Redox; active

The project aims are the synthesis of a novel patterned dendrimers with a specific function into core (redox-active matrix i.e. 4,4-bipyridine units) and a recognition function on the periphery (a biologically active label i.e. purine or pyrimidine bases) and the study of the physical and chemical properties as well as the interaction between biological substrate and such dendrimer systems. The project combines a structural variability of the polymer cores of the variable functionality of the peripheral in the sense of a modular system.In this way, can be produced, new materials with: (i) a high selectivity at specific recognition reactions; (Ii) a rapid detection by the attached redox label; (Iii) individually adapted design of nanoscale, molecular units with high reproducibility by recognition properties; (Iv) ionic liquid crystal properties with localized redox functions (electron / ion transfer); (V) Anti-HIV-1 / anti-cancer X4 activities by interacting with the chemokine receptor CXCR4.

该项目的目标是合成一种新型的图案化树状聚合物，其核心具有特定功能（氧化还原活性基质，即4，4-联吡啶单元），外围具有识别功能（生物活性标记，即嘌呤或嘧啶碱基），并研究其物理和化学性质以及生物基质与此类树状聚合物系统之间的相互作用。该项目结合了外围可变功能的聚合物核心的结构可变性，在模块化系统的意义上。以这种方式，可以生产新材料：（i）在特定识别反应中的高选择性;（Ii）通过附着的氧化还原标记进行快速检测;（iii）通过识别特性具有高再现性的纳米级分子单元的单独适应设计;（iii）通过识别特性具有高再现性的纳米级分子单元。（IV）具有局部氧化还原功能（电子/离子转移）的离子液晶性质;（V）通过与趋化因子受体CXCR 4相互作用的抗HIV-1 /抗癌X4活性。