Neurodevelopmental Effects of Prenatal Exposure to Maternal Drinking, Smoking and Adverse Psychosocial Factors: Deep Phenotyping of Infant CNS and ANS Function

产前暴露于母亲饮酒、吸烟和不良心理社会因素对神经发育的影响:婴儿 CNS 和 ANS 功能的深层表型分析

基本信息

项目摘要

PROJECT SUMMARY Alcohol use and smoking during pregnancy often occur in the context of maternal anxiety and depression. However, little is known regarding how different combinations of maternal alcohol use, smoking, and psychiatric symptoms interact to alter early central and autonomic nervous system (CNS, ANS) development and subsequent neurobehavioral outcomes in offspring. To better understand these relationships, this grant proposes to comprehensively characterize maternal alcohol, smoking, depression, and anxiety patterns during pregnancy via machine learning and artificial intelligence methodologies; to perform deep phenotyping of electrocortical and physiological data from infants; to test the overall hypothesis that physiology-derived measures mediate the relationship between maternal prenatal exposures and subsequent child neurodevelopmental outcomes. To accomplish these goals, this research proposes to use existing data from the completed Safe Passage Study conducted by the NIH funded Prenatal Alcohol in SIDS and Stillbirth (PASS) Network and from recently completed follow-up studies which enrolled subsets of the PASS participants. PASS cohort participants are from geographically and socio-economically diverse regions in South Africa and the Northern Plains of the United States. The extant PASS database comprises a detailed documentation of daily alcohol and smoking exposure and prenatal depression/anxiety assessments collected for 10,325 maternal/infant dyads and more than 1,000 variables which provide extensive information on maternal-fetal-infant medical history, demographics, and socio-economic status. These exposure data will be analyzed in relation to neonatal CNS/ANS deep phenotyping profiles derived from the analysis of 3,355 infant electroencephalograms (EEG) and electrocardiogram (ECG) data recorded either at birth or at one month of age. The extant neurobehavioral outcomes data were collected in four distinct cohorts of participants originally enrolled in PASS and followed up at 12 months (n=849) and 24-37 months of age (n=667). The follow-up study datasets contain item-level data, sub-test raw scores, and scaled-scores for the Mullen scales of early learning, the Parent Report of Children’s Abilities-Revised (PARCA-R), the Bayley scales of infant development III screening test and the Modified Checklist for Autism in Toddlers Revised with Follow up (M-CHAT-R/F). The proposed approach is expected to elucidate mechanisms of suboptimal neurodevelopment and resilience, and ultimately inform screenings for at-risk groups. Additionally, the proposed comprehensive deep phenotyping is intended to identify markers that are potential mediators of the relationship between prenatal exposures and outcomes. We anticipate that our findings will capitalize on the geocultural diversity of our cohorts and provide meaningful information associated with health disparities in underrepresented populations.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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William P. Fifer其他文献

Racial/ethnic disparities in sleep disorder breathing during pregnancy
  • DOI:
    10.1016/j.ajog.2021.11.602
  • 发表时间:
    2022-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Maristella Lucchini;Yael K. Rayport;William P. Fifer;Sanja Jelic;Carmela Alcántara;Louise M. O’Brien
  • 通讯作者:
    Louise M. O’Brien
Infant sleep state coded from respiration and its relationship to the developing functional connectome: A feasibility study
基于呼吸对婴儿睡眠状态的编码及其与正在发育的功能连接组的关系:一项可行性研究
  • DOI:
    10.1016/j.dcn.2025.101525
  • 发表时间:
    2025-04-01
  • 期刊:
  • 影响因子:
    4.900
  • 作者:
    Isabelle Mueller;Raimundo X. Rodriguez;Nicolò Pini;Cristin M. Holland;Rachel Ababio;Sanjana Inala;Kayla Delapenha;Venus Mahmoodi;Milana Khaitova;Xuejun Hao;William P. Fifer;Dustin Scheinost;Marisa N. Spann
  • 通讯作者:
    Marisa N. Spann
Maternal gestational diabetes mellitus (GDM) moderates the association between birth weight and (EEG) power in healthy term-age newborns
产妇妊娠期糖尿病(GDM)调节健康足月儿出生体重与(脑电图)功率之间的关联
  • DOI:
    10.1016/j.psyneuen.2023.106746
  • 发表时间:
    2024-02-01
  • 期刊:
  • 影响因子:
    3.600
  • 作者:
    Lauren Shuffrey;Nicolò Pini;Han Mei;Cynthia Rodriguez;Lissete A. Gimenez;Jennifer R. Barbosa;Daianna J. Rodriguez;Yael Rayport;Ayesha Sania;Catherine Monk;William P. Fifer
  • 通讯作者:
    William P. Fifer

William P. Fifer的其他文献

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{{ truncateString('William P. Fifer', 18)}}的其他基金

Neurodevelopmental Effects of Prenatal Exposure to Maternal Drinking, Smoking and Adverse Psychosocial Factors: Deep Phenotyping of Infant CNS and ANS Function
产前暴露于母亲饮酒、吸烟和不良心理社会因素对神经发育的影响:婴儿 CNS 和 ANS 功能的深层表型分析
  • 批准号:
    10596127
  • 财政年份:
    2022
  • 资助金额:
    $ 43.12万
  • 项目类别:
Perinatal Assessment of At-Risk Populations
高危人群的围产期评估
  • 批准号:
    8699897
  • 财政年份:
    2013
  • 资助金额:
    $ 43.12万
  • 项目类别:
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) Network
婴儿猝死综合症和死产中的产前酒精 (PASS) 网络
  • 批准号:
    7932581
  • 财政年份:
    2009
  • 资助金额:
    $ 43.12万
  • 项目类别:
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) Network
婴儿猝死综合症和死产中的产前酒精 (PASS) 网络
  • 批准号:
    7504003
  • 财政年份:
    2006
  • 资助金额:
    $ 43.12万
  • 项目类别:
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) Network
婴儿猝死综合症和死产中的产前酒精 (PASS) 网络
  • 批准号:
    7928196
  • 财政年份:
    2006
  • 资助金额:
    $ 43.12万
  • 项目类别:
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) Network
婴儿猝死综合症和死产中的产前酒精 (PASS) 网络
  • 批准号:
    8701599
  • 财政年份:
    2006
  • 资助金额:
    $ 43.12万
  • 项目类别:
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) Network
婴儿猝死综合症和死产中的产前酒精 (PASS) 网络
  • 批准号:
    7678959
  • 财政年份:
    2006
  • 资助金额:
    $ 43.12万
  • 项目类别:
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) Network
婴儿猝死综合症和死产中的产前酒精 (PASS) 网络
  • 批准号:
    8335188
  • 财政年份:
    2006
  • 资助金额:
    $ 43.12万
  • 项目类别:
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) Network
婴儿猝死综合症和死产中的产前酒精 (PASS) 网络
  • 批准号:
    7286775
  • 财政年份:
    2006
  • 资助金额:
    $ 43.12万
  • 项目类别:
Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) Network
婴儿猝死综合症和死产中的产前酒精 (PASS) 网络
  • 批准号:
    8204097
  • 财政年份:
    2006
  • 资助金额:
    $ 43.12万
  • 项目类别:

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