Understanding the efficacy of therapeutic antibodies through their interaction with cellular receptors.
Understanding the efficacy of therapeutic antibodies through their interaction with cellular receptors.
批准号:
20H03228
负责人:
CAAVEIRO Jose
金额:
$11.48万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2020
资助国家:
日本
项目状态:
已结题
起止时间:
2020-04-01 至 2023-03-31
中文摘要
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英文摘要
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile.
在CDRH3环上的芳香族性局灶性积累可减轻4E10的多反应性,而不会改变其HIV中和谱。
DOI:
10.1016/j.isci.2021.102987
发表时间:
2021-09-24
期刊:
iScience
影响因子:
5.8
作者:
[Rujas E, Leaman DP, Insausti S, Carravilla P, García-Porras M, Largo E, Morillo I, Sánchez-Eugenia R, Zhang L, Cui H, Iloro I, Elortza F, Julien JP, Eggeling C, Zwick MB, Caaveiro JMM, Nieva JL]
通讯作者:
Nieva JL
Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments.
接口的亲和力是在膜环境中运行的抗体的效力。
DOI:
10.1016/j.celrep.2020.108037
发表时间:
2020-08-18
期刊:
Cell reports
影响因子:
8.8
作者:
[Rujas E, Insausti S, Leaman DP, Carravilla P, González-Resines S, Monceaux V, Sánchez-Eugenia R, García-Porras M, Iloro I, Zhang L, Elortza F, Julien JP, Saéz-Cirión A, Zwick MB, Eggeling C, Ojida A, Domene C, Caaveiro JMM, Nieva JL]
通讯作者:
Nieva JL
Thermodynamic basis of life: protein-carbohydrate interaction
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批准号:15K06962
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2015
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负责人:CAAVEIRO Jose
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依托单位:
海外基金