Predictive role of long-term cortisol levels in hair for the development of posttraumatic stress disorder after rape exposure

头发中长期皮质醇水平对强奸暴露后创伤后应激障碍发展的预测作用

• 批准号: 322862470
• 负责人: Professor Dr. Clemens Kirschbaum
• 金额: --
• 依托单位: Professur für Biopsychologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/322862470?language=en
• 关键词: Predictive; role; long; term; cortisol

Only a relative minority of people who experience a traumatic event develop the clinical condition of posttraumatic stress disorder (PTSD). An important factor increasing individual vulnerability to PTSD appears to be attenuated secretion of the psychoactive glucocorticoid cortisol. However, due to a lack of adequately powered longitudinal prospective studies on this topic and limitations in previously employed measurement approaches, it is still unknown whether dysregulated cortisol production is a predisposing factor for PTSD or, alternatively, whether such endocrine changes mainly comprise a long-term response to trauma exposure.This proposal comprises a first longitudinal prospective cohort study examining the predictive value of pre- and post-traumatic hair cortisol concentrations (HCC) for subsequent PTSD symptom development in a large sample of severely traumatized women. Female rape victims (n = 580) will be assessed in the immediate aftermath of trauma and followed up at 3-months intervals over the subsequent year (3, 6, 9 and 12 months post-rape). An age and location-matched non-exposed control group (n = 580) will be studied in parallel. At each time point, hair samples will be collected together with detailed clinical, psychosocial and health-related data from both groups. The nature of HCC assessments, capturing hormone levels over the previous 3-month period, will for the first time enable a retrospective examination of the role of cortisol secretion before trauma exposure. In addition, the unique study design will allow for uncovering the pattern and time course of trauma-induced cortisol changes. The results of this project are likely to lead to novel insights into psychoendocrine determinants of PTSD and to inform future person-centered approaches to prevent the development of PTSD in traumatized individuals.

只有相对少数经历过创伤事件的人会出现创伤后应激障碍(PTSD)的临床状况。增加个体对创伤后应激障碍易感性的一个重要因素似乎是精神活性糖皮质醇分泌减弱。然而，由于缺乏足够有力的纵向前瞻性研究，以及以前采用的测量方法的局限性，目前仍不清楚皮质醇分泌失调是否是创伤后应激障碍的诱因，或者，这种内分泌变化是否主要包括对创伤暴露的长期反应。这项建议包括第一项纵向前瞻性队列研究，在大样本严重创伤女性中，检测创伤前和创伤后头发皮质醇浓度(HCC)对随后PTSD症状发展的预测价值。580名女性强奸受害者将在创伤后立即接受评估，并在随后一年(强奸后3个月、6个月、9个月和12个月)每隔3个月进行跟踪。一个年龄和位置匹配的非暴露对照组(n=580)将被平行研究。在每个时间点，头发样本将被收集，以及来自两组的详细的临床、心理社会和健康相关数据。肝细胞癌评估的性质，获取前3个月内的激素水平，将首次使创伤暴露前皮质醇分泌的作用得以回顾检查。此外，独特的研究设计将允许揭示创伤引起的皮质醇变化的模式和时间过程。该项目的结果可能导致对创伤后应激障碍的心理内分泌决定因素的新见解，并为未来以人为中心的方法提供信息，以防止创伤后应激障碍的发展。

项目成果

Hair cortisol as a biomarker of stress and resilience in South African mixed ancestry females

头发皮质醇作为南非混血女性压力和恢复力的生物标志物

• DOI: 10.1016/j.psyneuen.2019.104543
• 发表时间: 2020
• 期刊: Psychoneuroendocrinology
• 影响因子: 3.7
• 作者: van den Heuvel;du Plessis;Stalder;Suliman;Thorne;Kirschbaum;Seedat
• 通讯作者: Seedat

Hair cortisol levels in posttraumatic stress disorder and metabolic syndrome

• DOI: 10.1080/10253890.2020.1724949
• 发表时间: 2020-02
• 期刊: Stress
• 作者: L. L. van den Heuvel-L.;T. Stalder;S. du Plessis;S. Suliman;C. Kirschbaum;S. Seedat