Development of Raman spectroscopy for the enantioselective analysis of chiral media

用于手性介质对映选择性分析的拉曼光谱的发展

• 批准号: 324478153
• 负责人: Professor Dr.-Ing. Johannes Kiefer
• 金额: --
• 依托单位: Fachgebiet Technische Thermodynamik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/324478153?language=en
• 关键词: Development; Raman; spectroscopy; enantioselective; analysis

Chiral molecules play an important role in our everyday lives, e.g. as pharmaceutically active ingredients. Their physiological effects are usually highly dependent on the enantiomer. Therefore, it is important to produce these substances with high enantiomeric purity. However, a major difficulty in this context is the discrimination of the different enantiomers of a chiral substance. This is particularly true with regard to the monitoring of the production process. It is very common to take a sample and analyze it offline in the lab. This project aims at overcoming this problem by developing a new analytical method based on Raman spectroscopy. This method will enable enantioselective measurements and hence provide a tool for online process monitoring. The method utilizes the intrinsic optical activity of chiral media. Systematic experiments and the development of a mathematical model will be used to examine different possible approaches. The knowledge to be gained will allow to identify a concept that is suitable for process monitoring applications. In addition, the enantioselective Raman technique will be applied to characterize selected chiral systems systematically. This will allow to identify potentials and limitations of the method.

手性分子在我们的日常生活中扮演着重要的角色，例如作为药物活性成分。它们的生理作用通常高度依赖于对映体。因此，生产这些对映体纯度高的物质是很重要的。然而，在这方面的一个主要困难是手性物质的不同对映体的区分。在生产过程的监测方面尤其如此。取一个样本并在实验室离线分析是很常见的。本项目旨在通过开发一种新的基于拉曼光谱的分析方法来克服这一问题。这种方法将使对映选择性测量成为可能，因此为在线过程监测提供了一种工具。该方法利用了手性介质的本征旋光性。系统的实验和数学模型的发展将被用来检验不同可能的方法。所获得的知识将允许确定一个适用于过程监控应用的概念。此外，对映选择性拉曼技术将被应用于系统地表征选定的手性体系。这将有助于识别该方法的潜力和局限性。