Development of Raman spectroscopy for the enantioselective analysis of chiral media

手性分子在我们的日常生活中扮演着重要的角色，例如作为药物活性成分。它们的生理作用通常高度依赖于对映体。因此，生产具有较高对映体纯度的这类物质具有重要意义。然而，在这方面的一个主要困难是对手性物质的不同对映体的区分。在监测生产过程方面尤其如此。在实验室中进行离线样本分析是很常见的。本项目旨在通过发展一种新的基于拉曼光谱的分析方法来克服这一问题。这种方法将使对映体选择性测量成为可能，从而为在线过程监测提供工具。该方法利用了手性介质的固有旋光性。系统的实验和数学模型的开发将被用来研究不同的可能方法。将获得的知识将允许确定适用于过程监控应用的概念。此外，还将利用对映体选择性拉曼技术对所选择的手性体系进行系统表征。这将允许确定该方法的潜力和局限性。

Chiral molecules play an important role in our everyday lives, e.g. as pharmaceutically active ingredients. Their physiological effects are usually highly dependent on the enantiomer. Therefore, it is important to produce these substances with high enantiomeric purity. However, a major difficulty in this context is the discrimination of the different enantiomers of a chiral substance. This is particularly true with regard to the monitoring of the production process. It is very common to take a sample and analyze it offline in the lab. This project aims at overcoming this problem by developing a new analytical method based on Raman spectroscopy. This method will enable enantioselective measurements and hence provide a tool for online process monitoring. The method utilizes the intrinsic optical activity of chiral media. Systematic experiments and the development of a mathematical model will be used to examine different possible approaches. The knowledge to be gained will allow to identify a concept that is suitable for process monitoring applications. In addition, the enantioselective Raman technique will be applied to characterize selected chiral systems systematically. This will allow to identify potentials and limitations of the method.