Development of multi-stimuli-responsive metallodrugs

多重刺激响应金属药物的开发

• 批准号: 20K05456
• 负责人: Hirahara Masanari
• 金额: $ 2.75万
• 依托单位: Osaka Institute of Technology (2021-2022)防衛大学校(総合教育学群、人文社会科学群、応用科学群、電気情報学群及びシステム工学群) (2020)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K05456/
• 关键词: ルテニウム; 光配位子置換反応; 抗がん剤; 光反応; 光異性化; メタロドラッグ; 配位子交換反応; 外部刺激応答; プロドラッグ; 金属錯体; 光化学

项目成果

Distinctive Aspects in Aquation, Proton-Coupled Redox, and Photoisomerization Reactions between Geometric Isomers of Mononuclear Ruthenium Complexes with a Large-π-Conjugated Tetradentate Ligand

单核钌配合物与大π-共轭四齿配体的几何异构体之间的水合、质子耦合氧化还原和光异构化反应的独特之处

• DOI: 10.1021/acs.inorgchem.2c01937
• 发表时间: 2022
• 期刊: Inorganic Chemistry
• 影响因子: 4.6
• 作者: Tsubonouchi Yuta;Watanabe Takeumi;Yoshida Kazuha;Watabe Shunsuke;Inaba Keisuke;Hirahara Masanari;Hatanaka Tsubasa;Funahashi Yasuhiro;Chandra Debraj;Hoshino Norihisa;Zahran Zaki N.;Yagi Masayuki
• 通讯作者: Yagi Masayuki

Ruthenium Pyrazole-Pyrazolate Complexes: Unique Photosubstitution Reactions and Applications to Photoactivated Chemotherapeutic Prodrugs

吡唑-吡唑酸钌配合物：独特的光取代反应及其在光活化化疗前药中的应用

• 发表时间: 2023
• 作者: Masanari HIRAHARA;Yuto TERAOKA; Keiichi FUJIMORI;Takayo MORIUCHI;Takamasa UEKITA
• 通讯作者: Takamasa UEKITA

Efficient Electrocatalytic Water Oxidation by a Dinuclear Ruthenium(II) Complex with Vicinal Aquo and Hydroxo Groups Adsorbed on a TiO2 Electrode

TiO2 电极上吸附有邻位水基和羟基的双核钌 (II) 络合物的高效电催化水氧化

• DOI: 10.1021/acsaem.0c02242
• 发表时间: 2020
• 期刊: ACS Applied Energy Materials
• 影响因子: 6.4
• 作者: Tanahashi Yuki;Nagai Sho;Tsubonouchi Yuta;Hirahara Masanari;Sato Taisei;Mohamed Eman A.;Zahran Zaki N.;Saito Kenji;Yui Tatsuto;Yagi Masayuki
• 通讯作者: Yagi Masayuki

A Multi-Stimuli-Responsive Water Oxidation Catalyst

多刺激响应水氧化催化剂

• 发表时间: 2020
• 作者: Masanari Hirahara;Hiroki Goto;Yasushi Umemura
• 通讯作者: Yasushi Umemura

Mechanism of H ⁺ dissociation?induced O?O bond formation via intramolecular coupling of vicinal hydroxo ligands on low-valent Ru(III) centers

H  解离机制？通过低价 Ru(III) 中心上邻位羟基配体的分子内偶联诱导 O?O 键形成

• DOI: 10.1073/pnas.2113910118
• 发表时间: 2021
• 期刊: Proceedings of the National Academy of Sciences
• 作者: Tanahashi Yuki;Takahashi Kosuke;Tsubonouchi Yuta;Nozawa Shunsuke;Adachi Shin-ichi;Hirahara Masanari;Mohamed Eman A.;Zahran Zaki N.;Saito Kenji;Yui Tatsuto;Yagi Masayuki
• 通讯作者: Yagi Masayuki