Development of sustainable heterogeneous catalysts for step-efficient synthesis of selective oncology drug intermediates.

开发可持续的多相催化剂，用于选择性肿瘤药物中间体的高效合成。

• 批准号: 20K05576
• 负责人: Touchy AbedaSultana
• 金额: $ 2.75万
• 依托单位: Tokyo Metropolitan University (2021)Hokkaido University (2020)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K05576/
• 关键词: Heterogeneous catalysis; Step-efficient Synthesis; Oncology drug; Heterogeneous Catalysis; API Intermediates; Green Synthesis; Acceptorless; Metal nanoparticles

To develop the heterogeneous catalytic methods for the proposed plan, the reactions (1) Dehydrogenative selective methylation and reductive amination of 2-aminobenzamide derivative to quinazolin-4-amine derivative, (2) Dehydrogenative heterocyclization reaction of 1,2-diamino benzene derivative in reaction with methanol produced benzimidazole derivatives, and (3) Hydrolysis of triglycerides to fatty acids are being demonstrated by employing sustainable and environmentally benign green synthesis methods.For the reactions 1-3 we identified effective catalysts. Further optimization, demonstration, kinetics and mechanistic studies are underway for reactions 1 and 2. For the reaction 3 we have already submitted the paper and it is under review.

为开发多相催化方法，通过(1)2-氨基苯酰胺衍生物的脱氢选择性甲基化和还原胺化反应生成喹唑啉-4-胺衍生物，(2)1,2-二氨基苯衍生物与甲醇反应的脱氢杂环化反应生成苯并咪唑衍生物，(3)采用可持续和环保的绿色合成方法，证明甘油三酯水解成脂肪酸。对于反应1-3，我们确定了有效的催化剂。反应1和反应2的进一步优化、论证、动力学和机理研究正在进行中。对于反应3，我们已经提交了论文，正在审查中。

项目成果

Lewis Acid Promoted Sustainable Transformation of Triglycerides to Fatty Acids Using Water Tolerant Nb2O5 Catalyst

路易斯酸使用耐水 Nb2O5 催化剂促进甘油三酯向脂肪酸的可持续转化

• 发表时间: 2021
• 作者: Yokoi K;Kato D;Miura K;S. M. A. Hakim Siddiki
• 通讯作者: S. M. A. Hakim Siddiki

Hydrolysis of amides to carboxylic acids catalyzed by Nb2O5

• DOI: 10.1039/d0cy02230f
• 发表时间: 2021-03
• 期刊: Catalysis Science & Technology
• 影响因子: 5
• 作者: S. H. Siddiki;Md. Nurnobi Rashed;A. S. Touchy;Md. A. R. Jamil;Yuan Jing;Takashi Toyao;Z. Maeno;K. Shimizu

Acceptorless borrowing-hydrogen/dehydrogenative type coupling reactions of alcohols using heterogeneous metal nanocluster catalysts

使用非均相金属纳米簇催化剂的醇的无受体借氢/脱氢型偶联反应

• 发表时间: 2021
• 作者: Siddiki S. M. A. Hakim;Rashed Md. Nurnobi;Touchy Abeda Sultana;Jamil Md. A. R.;Jing Yuan;Toyao Takashi;Maeno Zen;Shimizu Ken-ichi;S. M. A. Hakim Siddiki
• 通讯作者: S. M. A. Hakim Siddiki

Dehydrogenative one-pot Synthesis of Pyrazines from Glycerol and Ammonia using Pt Nanoparticle Catalyst

Pt纳米颗粒催化剂以甘油和氨为原料一锅法脱氢合成吡嗪

• 发表时间: 2021
• 作者: Yokoi K;Kato D;Miura K;S. M. A. Hakim Siddiki;Abeda Sultana Touchy
• 通讯作者: Abeda Sultana Touchy