Spatiotemporal dynamics of a membrane-associated RNA-binding protein and its cargo in Vibrio cholerae (P15)

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In this project, we will characterize a novel RNA-binding protein encoded on the chromosome of the major human pathogen Vibrio cholerae. This protein, named MbrA (membrane-bound RNA-binding protein A), localizes to the cytoplasmic membrane and binds cellular RNA through a conserved RRM-type RNA-binding domain. Cells deficient for MbrA fail to perform intercellular communication, suggesting that subcellular localization of RNAs could affect complex behaviour in V. cholerae.