Konfokales Lasermikroskop

共焦激光显微镜

• 批准号: 326611512
• 金额: --
• 依托单位: Klinikum der Universität München
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/326611512?language=en
• 关键词: Konfokales; Lasermikroskop

We study human rare diseases of the blood and the immune system with the aim to reveal molecular mechanisms of haematopoiesis and immunity. We are particularly interested in investigating the dynamics of intracellular transport within innate immune cells. To analyse and quantify these complex and rapid processes, a state-of-the-art high-resolution laser-confocal microscope with the possibility to perform live-cell imaging constitutes an essential core equipment. In summer 2015, a basic confocal microscope that had been present in the KUBUS Research Center was moved to the University of Düsseldorf together with the group of Prof. Ensenauer. A basic confocal microscope belonging to AG Endres is available, yet this microscope is heavily used and is not equipped with high sensitivity detectors. However, to advance our ongoing and planned projects (funded by DFG, ERC, BMBF and others), additional microscope time and a device offering the latest technical advancements, high resolution capacities and optimal detector quality are indispensable prerequisites. Not only the applicant, but also the co-applicants from across the disciplines represented in the KUBUS Research Center depend on and will highly profit from the microscope.

我们研究人类罕见的血液和免疫系统疾病，旨在揭示造血和免疫的分子机制。我们特别感兴趣的是研究先天性免疫细胞内的细胞内运输动力学。为了分析和量化这些复杂而快速的过程，最先进的高分辨率激光共聚焦显微镜具有执行活细胞成像的可能性，构成了一个必不可少的核心设备。2015年夏天，KUBUS研究中心的基础共聚焦显微镜与Ensenauer教授的团队一起搬到了杜塞尔多夫大学。AG Endres公司有一种基本的共聚焦显微镜，但这种显微镜使用量很大，没有配备高灵敏度的探测器。然而，为了推进我们正在进行和计划中的项目（由DFG，ERC，BMBF和其他资助），额外的显微镜时间和提供最新技术进步，高分辨率能力和最佳检测器质量的设备是不可或缺的先决条件。不仅申请人，而且来自KUBUS研究中心所代表的各个学科的共同申请人都依赖于显微镜，并将从中获益匪浅。