The Regulome controls adaptive lymphocyte development and DNA recombinase Rag1/Rag2 expression

Regulome 控制适应性淋巴细胞发育和 DNA 重组酶 Rag1/Rag2 表达

• 批准号: 19H03487
• 负责人: Miyazaki Masaki
• 金额: $ 11.15万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19H03487/
• 关键词: 獲得免疫; Rag1 Rag2; T, B細胞; 遺伝子再構成; エンハンサー; ゲノム構造; 転写因子; E2A; adaptive lymphocyte; T cell and B cell; Rag1 and Rag2 expression; enhancer regulation; super-enhancer formation; V(D)J DNA recombination; 獲得免疫リンパ球; Rag遺伝子; ３次元ゲノム構造変換; 転写因子E2A; ３

项目成果

The Evolution of Rag Gene Enhancers and Transcription Factor E and Id Proteins in the Adaptive Immune System.

• DOI: 10.3390/ijms22115888
• 发表时间: 2021-05-31
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Yoshikawa G;Miyazaki K;Ogata H;Miyazaki M
• 通讯作者: Miyazaki M

E2A specifies adaptive immunity by instructing large-scale topological changes for Rag gene super-enhancer formation.

E2A 通过指示 Rag 基因超级增强子形成的大规模拓扑变化来指定适应性免疫。

• 发表时间: 2021
• 作者: Miyazaki Kazuko;Watanabe Hitomi;Yoshikawa Genki;Chen Kenian;Hidaka Reiko;Aitani Yuki;Osawa Kai;Takeda Rie;Ochi Yotaro;Tani-ichi Shizue;Uehata Takuya;Takeuchi Osamu;Ikuta Koichi;Ogawa Seishi;Kondoh Gen;Lin Yin C.;Ogata Hiroyuki;Miyazaki Masaki;Masaki Miyazaki
• 通讯作者: Masaki Miyazaki

Conserved two E-box sequences neighboring the Rag1-promoter is critically required for the initiation of Rag1 gene expression upon T and B cell lineage commitment; Distinct gene regulation mediated by enhancers and promoter for adaptive immunity

与 Rag1 启动子相邻的两个保守的 E-box 序列对于在 T 和 B 细胞谱系定型时启动 Rag1 基因表达至关重要；

• 发表时间: 2021
• 作者: Miyazaki Kazuko;Watanabe Hitomi;Yoshikawa Genki;Chen Kenian;Hidaka Reiko;Aitani Yuki;Osawa Kai;Takeda Rie;Ochi Yotaro;Tani-ichi Shizue;Uehata Takuya;Takeuchi Osamu;Ikuta Koichi;Ogawa Seishi;Kondoh Gen;Lin Yin C.;Ogata Hiroyuki;Miyazaki Masaki;Masaki Miyazaki;Masaki Miyazaki
• 通讯作者: Masaki Miyazaki

The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells

• DOI: 10.1126/sciimmunol.abb1455
• 发表时间: 2020-09-01
• 期刊: SCIENCE IMMUNOLOGY
• 影响因子: 24.8
• 作者: Miyazaki, Kazuko;Watanabe, Hitomi;Miyazaki, Masaki
• 通讯作者: Miyazaki, Masaki

The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation of Rag Gene Expression.

• DOI: 10.3389/fimmu.2021.659761
• 发表时间: 2021
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Miyazaki K;Miyazaki M
• 通讯作者: Miyazaki M