Neurological cell replacement therapies: improving outcomes by matching developmental profiles of transplanted cells with the damaged brain area.

神经细胞替代疗法：通过将移植细胞的发育特征与受损大脑区域相匹配来改善结果。

• 批准号: DP0772899
• 负责人: Dr Meghan Thomas
• 金额: $ 17.55万
• 依托单位: Edith Cowan University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-06-25 至 2011-06-12
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0772899
• 关键词: Neurological; cell; replacement; therapies; improving

Stem cell transplantation offers a way to replace nerve cells lost due to acute CNS injury or chronic degenerative conditions such as Parkinson's Disease. However, to date, results have been disappointing because of poor differentiation, survival and integration of stem cells confounded by ethical issues associated with the use of embryos as the source of stem cells. The experiments conducted in this study will provide strategies to improve the efficacy of stem cell transplantation into the damaged CNS as well as developing the use of autologous bone marrow stem cells for repair. Outcomes will be improved transplant methodologies and expertise for the bio-technology industry.

干细胞移植提供了一种替代由于急性中枢神经系统损伤或慢性退行性疾病（如帕金森病）而丢失的神经细胞的方法。然而，迄今为止，结果令人失望，因为干细胞的分化、存活和整合较差，这受到与使用胚胎作为干细胞来源相关的伦理问题的混淆。在这项研究中进行的实验将提供策略，以提高干细胞移植到受损的中枢神经系统的疗效，以及开发使用自体骨髓干细胞进行修复。其成果将是改进移植方法和生物技术行业的专门知识。