Neurological cell replacement therapies: improving outcomes by matching developmental profiles of transplanted cells with the damaged brain area.

干细胞移植提供了一种替代因急性中枢神经系统损伤或慢性退行性疾病（如帕金森病）而丢失的神经细胞的方法。然而，到目前为止，由于干细胞分化、存活和整合能力差，以及与使用胚胎作为干细胞来源相关的伦理问题，结果令人失望。本研究的实验将为提高干细胞移植到受损中枢神经系统的疗效以及开发使用自体骨髓干细胞进行修复提供策略。结果将改进移植方法和生物技术行业的专业知识。

Stem cell transplantation offers a way to replace nerve cells lost due to acute CNS injury or chronic degenerative conditions such as Parkinson's Disease. However, to date, results have been disappointing because of poor differentiation, survival and integration of stem cells confounded by ethical issues associated with the use of embryos as the source of stem cells. The experiments conducted in this study will provide strategies to improve the efficacy of stem cell transplantation into the damaged CNS as well as developing the use of autologous bone marrow stem cells for repair. Outcomes will be improved transplant methodologies and expertise for the bio-technology industry.