Identification and characterization of major stem cell identity regulators within the epidermis (A13*)

表皮内主要干细胞身份调节因子的鉴定和表征 (A13*)

• 批准号: 339953989
• 金额: --
• 依托单位: Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/339953989?language=en
• 关键词: Identification; characterization; major; stem; cell

The epidermis contains a great variety of functionally and spatially distinct stem cell populations that play important roles during skin homeostasis, wound healing, ageing and disease. Despite their functional and medical relevance, most epidermis stem cell populations remain poorly characterized at a molecular level. Using a recently established epigenomic approach that facilitates the molecular dissection of cellular heterogeneity, we aim at uncovering and functionally characterizing the major regulators of the distinct stem cell compartments residing within the Epidermis.

表皮含有多种功能和空间上不同的干细胞群体，其在皮肤稳态、伤口愈合、衰老和疾病期间发挥重要作用。尽管它们的功能和医学相关性，大多数表皮干细胞群体仍然在分子水平上表征不佳。使用最近建立的表观基因组的方法，有利于细胞异质性的分子解剖，我们的目标是发现和功能特性的主要监管机构的不同干细胞隔室居住在表皮。