Repetitive Transcranial Magnetic Stimulation (rTMS) for the treatment of chronic Tinnitus

重复经颅磁刺激（rTMS）治疗慢性耳鸣

• 批准号: 33974584
• 负责人: Professor Dr. Göran Hajak
• 金额: --
• 依托单位: Klinik für Psychiatrie, Psychotherapie u. Psychosomatik
• 依托单位国家: 德国
• 项目类别: Clinical Trials
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/33974584?language=en
• 关键词: Repetitive; Transcranial; Magnetic; Stimulation; rTMS

Chronic tinnitus is a debilitating and life-altering experience affecting millions of people in western countries. Despite its enormous social and ecomic burden, up to now no well-established specific treatment for this disorder is available. While traditionally chronic tinnitus has been viewed as having a purely auditory etiology, growing evidence underscore abnormal functioning of the central nervous system including hyperactivity of the auditory cortex and maladaptive neuroplasticity in distinct cortical networks. Repetitive Transcranial Magnetic Stimulation (rTMS) is a new biophysical treatment method which applied in a low-frequency range has shown to reduce brain hyperexcitability and to modulate neuroplasticity in critical cortical circuits. Based on these neurobiological qualities and used as a causally-orientated treatmant strategy, low-frequency rTMS was able to improve tinnitus complaints significantly beyond the stimulation period in several clinical trials. Simultaneously, beneficial therapeutical response was associated with selective changes in neurobiological mechanisms, pointing to alterations in neuroplasticity as crucial for the mediation of treatment effects. Aiming at a systematic investigation based on a large sample size, the proposed randomized controlled multicenter trial will study the efficacy of low frequency rTMS in the treatment of chronic tinnitus and will focus to elucidate neurobiological mechanisms underlying rTMS induced clinical effects.

慢性耳鸣是一种使人衰弱和改变生活的经历，影响着西方国家数百万人。尽管其巨大的社会和经济负担，到目前为止还没有成熟的具体治疗这种疾病。虽然传统上慢性耳鸣被视为具有纯粹的听觉病因，但越来越多的证据强调中枢神经系统的功能异常，包括听觉皮层的过度活跃和不同皮层网络中的适应不良神经可塑性。重复经颅磁刺激（rTMS）是一种新的生物物理治疗方法，应用在低频范围内，已显示出减少大脑过度兴奋和调节关键皮层回路的神经可塑性。基于这些神经生物学特性，并作为一种因果导向的治疗策略，低频rTMS能够在几项临床试验中显着改善耳鸣投诉超过刺激期。同时，有益的治疗反应与神经生物学机制的选择性变化相关，指出神经可塑性的改变对于调节治疗效果至关重要。该随机对照多中心试验旨在进行大样本量的系统研究，将研究低频rTMS治疗慢性耳鸣的疗效，并将重点阐明rTMS诱导临床效应的神经生物学机制。