Repetitive Transcranial Magnetic Stimulation Augmented Written Exposure Therapy for Veterans with PTSD
针对患有 PTSD 的退伍军人的重复经颅磁刺激增强书面暴露疗法
基本信息
- 批准号:10260136
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-01-01 至 2026-12-31
- 项目状态:未结题
- 来源:
- 关键词:AffectAffectiveAffective SymptomsAppointmentAreaAttentionAwardBase of the BrainBehavior TherapyBehavioral MechanismsBrainCenters of Research ExcellenceClinicClinicalClinical TreatmentClinical TrialsCognitionCognitiveCollaborationsDiagnosisDoseDouble-Blind MethodDown-RegulationEffectivenessElectromagneticsEmotionalEmotionsFellowshipFreedomFutureGoalsHealthcareIndividual DifferencesInterventionInvestigationLengthMagnetismMediatingMediator of activation proteinMental DepressionMental HealthMental disordersMentorsMissionNeuronsOutcomePatientsPhasePhysiologic pulsePositioning AttributePost-Traumatic Stress DisordersPrefrontal CortexProcessPropertyPsychotherapyQuality of CareRandomizedRandomized Controlled TrialsResearchResearch PersonnelSamplingScalp structureSiteSymptomsTestingTimeTrainingTraumaTreatment EffectivenessTreatment ProtocolsTreatment outcomeUp-RegulationVeteransWarWomanWorkbasebehavioral studybrain behaviorcareercognitive controlcognitive enhancementeffective interventioneffective therapyemotion dysregulationemotion regulationevidence baseexperienceflexibilityimprovedmenneuromechanismnoveloperationreduce symptomsrelating to nervous systemrepetitive transcranial magnetic stimulationsymptomatic improvementtheoriestrauma exposuretreatment effecttreatment-resistant depression
项目摘要
Post-traumatic stress disorder (PTSD) is highly prevalent among post-deployment Veterans. First
line evidence-based psychotherapies (EBPs) for PTSD can be effective, but have limitations
including high attrition rates, due in part to lengthy treatment protocols, and continued diagnosis of
PTSD in a significant number of patients despite treatment completion. Alternate brain-based
treatments are thus being explored, like repetitive transcranial magnetic stimulation (rTMS ), which
is useful for depression and shows promise for PTSD. rTMS involves applying a repetitive, brief
magnetic pulse to the scalp in order to safely modulate cortical neurons via the dorsolateral
prefrontal cortex node, which is believed to improve control of cognition and emotions. Standard
rTMS treatments are stand-alone, though the unique properties of rTMS enhancing cognitive
control may make it more effective when added to an EBP for PTSD. A brief EBP for PTSD that is
effective in as few as five sessions with limited attrition is written exposure therapy (WET).
Integration of rTMS with WET could improve efficacy by improving emotional control-dependent
cognitive restructuring, which is believed to be WET’s mechanism of action. However, this
possibility has not been tested.
The applicant, Dr. Lantrip, is a clinical neuropsychologist with expertise in brain -behavior
relationships. She has significant experience studying behavioral and neural regulatory processes
impacting mental health. Through her postdoctoral fellowship, she developed a theoretical
framework for understanding the emotion regulatory mechanisms contributing to symptom
improvement in rTMS for depression. She tested this theory in an rTMS clinical trial. Through her
current primary VA appointment at the VISN 17 Center of Excellence for Research on Returning
War Veterans, Dr. Lantrip has access to a large pool of Veterans with PTSD as well as to a
research-dedicated TMS machine. Further, Dr. Lantrip has established collaborations with external
researchers who are experts in rTMS treatment in Veterans and in WET. In short, Dr. Lantrip is in
an ideal position to conduct the necessary research to augment behavioral therapy for PTSD with
rTMS.
In the proposed randomized controlled trial, Dr. Lantrip will compare active rTMS added to WET
with sham rTMS added to WET in [98] Veterans with PTSD. She will also determine the
mechanism of action of the treatment by determining if emotional flexibility is a mediator of
treatment outcome.
In summary, this project will attempt to augment WET, a brief EBP for PTSD, by adding rTMS,
and it will also attempt to determine the emotion regulatory mechanism of action for symptom
improvement. If successful, this work will influence both clinical treatment and scientific
investigation of PTSD. This project will be of potentially great value to both patients and clinicians
within the VA by providing an effective, efficient treatment option for veterans with PTSD. This
treatment may also facilitate symptom improvement in transdiagnostic mental health disorders.
Upon successful completion of this project, Dr. Lantrip will apply for a VA Merit Review Award with
continued investigation into TMS-augmented behavioral intervention for trauma-related illness. By
providing Dr. Lantrip with mentored research time to conduct this study, this project will help Dr.
Lantrip achieve her goal of becoming an independent VA investigator.
创伤后应激障碍(PTSD)在退伍军人中非常普遍。第一的
针对 PTSD 的循证心理治疗 (EBP) 可能有效,但也有局限性
包括高流失率,部分原因是治疗方案冗长,以及持续诊断
尽管治疗已完成,仍有大量患者出现创伤后应激障碍(PTSD)。基于替代大脑
因此,人们正在探索治疗方法,例如重复经颅磁刺激(rTMS),
对治疗抑郁症很有用,并有望治疗创伤后应激障碍 (PTSD)。 rTMS 涉及应用重复、简短的
向头皮发出磁脉冲,以便通过背外侧安全地调节皮质神经元
前额皮质节点,被认为可以改善认知和情绪的控制。标准
尽管 rTMS 具有增强认知能力的独特特性,但 rTMS 治疗是独立的
当添加到针对 PTSD 的 EBP 中时,控制可能会更有效。 PTSD 的简短 EBP 是
书面暴露疗法(WET)仅需五次疗程即可有效,且损耗有限。
rTMS 与 WET 的整合可以通过改善情绪控制依赖性来提高疗效
认知重构,这被认为是 WET 的作用机制。然而,这
可能性尚未测试。
申请人Lantrip博士是一位临床神经心理学家,在大脑行为方面具有专业知识
关系。她在研究行为和神经调节过程方面拥有丰富的经验
影响心理健康。通过博士后研究,她开发了一种理论
理解导致症状的情绪调节机制的框架
rTMS 治疗抑郁症的改善。她在一项 rTMS 临床试验中测试了这一理论。通过她
目前在 VISN 17 回国研究卓越中心担任主要 VA 任命
Lantrip 博士可以接触到大量患有创伤后应激障碍 (PTSD) 的退伍军人以及
研究专用 TMS 机器。此外,Lantrip 博士还与外部建立了合作关系
研究人员是退伍军人 rTMS 治疗和 WET 方面的专家。简而言之,Lantrip 博士在
进行必要的研究以增强 PTSD 行为疗法的理想位置
经颅磁刺激。
在拟议的随机对照试验中,Lantrip 博士将比较添加到 WET 中的活性 rTMS
在[98]患有 PTSD 的退伍军人中,将假 rTMS 添加到 WET 中。她还将确定
通过确定情绪灵活性是否是治疗的作用机制
治疗结果。
总之,该项目将尝试通过添加 rTMS 来增强 WET(针对 PTSD 的简短 EBP),
它还将尝试确定症状的情绪调节作用机制
改进。如果成功,这项工作将影响临床治疗和科学
创伤后应激障碍(PTSD)调查。该项目对患者和临床医生都具有潜在的巨大价值
在 VA 范围内,为患有 PTSD 的退伍军人提供有效、高效的治疗选择。这
治疗还可能有助于跨诊断精神健康障碍的症状改善。
成功完成该项目后,Lantrip 博士将申请 VA 优异评审奖
继续研究 TMS 增强行为干预对创伤相关疾病的影响。经过
该项目为 Lantrip 博士提供指导研究时间来进行这项研究,该项目将帮助 Lantrip 博士。
Lantrip 实现了成为一名独立的 VA 调查员的目标。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Crystal Lantrip其他文献
Crystal Lantrip的其他文献
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{{ truncateString('Crystal Lantrip', 18)}}的其他基金
Repetitive Transcranial Magnetic Stimulation Augmented Written Exposure Therapy for Veterans with PTSD
针对患有 PTSD 的退伍军人的重复经颅磁刺激增强书面暴露疗法
- 批准号:
10402838 - 财政年份:2022
- 资助金额:
-- - 项目类别:
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