Prevention of type 2 diabetes by dietary protein restriction

这个基础科学项目的目标是预防和治疗代谢性疾病。长期目标是确定可能抵消2型糖尿病发展的饮食成分。收集到的数据表明，葡萄糖稳态和糖尿病的发病率不仅受到饮食中卡路里数量（能量含量）的影响，还受到饮食成分（蛋白质含量）的影响。因此，我们将使用新西兰肥胖小鼠（一种2型糖尿病模型）来研究膳食蛋白质含量是否对高热量（致糖尿病）饮食有影响，以及哪些内分泌信号可能负责抗糖尿病作用。

This basic science project targets the prevention and treatment of metabolic disease. The long term goal is to identify dietary components which might counteract the development of type 2 diabetes. Collected data indicate that glucose homeostasis and therefore the prevalence of diabetes is not only influenced by the number of calories (energy content) in the diet, but also by the composition (protein content) of the diet. For this reason, we will use the New Zealand Obese mouse, a model for type 2 diabetes, to investigate if the dietary protein content has an impact on a high-caloric (diabetogenic) diet and which endocrine signals may be responsible for the anti-diabetogenic effect.