Prevention of type 2 diabetes by dietary protein restriction

通过限制膳食蛋白质预防 2 型糖尿病

• 批准号: 339790145
• 负责人: Privatdozent Dr. Thomas Laeger
• 金额: --
• 依托单位: Institut für Ernährungsphysiologie "Oskar Kellner"
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/339790145?language=en
• 关键词: Prevention; type; diabetes; dietary; protein

This basic science project targets the prevention and treatment of metabolic disease. The long term goal is to identify dietary components which might counteract the development of type 2 diabetes. Collected data indicate that glucose homeostasis and therefore the prevalence of diabetes is not only influenced by the number of calories (energy content) in the diet, but also by the composition (protein content) of the diet. For this reason, we will use the New Zealand Obese mouse, a model for type 2 diabetes, to investigate if the dietary protein content has an impact on a high-caloric (diabetogenic) diet and which endocrine signals may be responsible for the anti-diabetogenic effect.

这个基础科学项目的目标是预防和治疗代谢性疾病。长期目标是确定可能抵消2型糖尿病发展的饮食成分。收集的数据表明，葡萄糖稳态和糖尿病的患病率不仅受到饮食中卡路里数量（能量含量）的影响，而且还受到饮食成分（蛋白质含量）的影响。出于这个原因，我们将使用新西兰肥胖小鼠（2型糖尿病模型）来研究膳食蛋白质含量是否对高热量（致糖尿病）饮食产生影响，以及哪些内分泌信号可能导致抗致糖尿病作用。

项目成果

Epigenetic regulation of hepatic Dpp4 expression in response to dietary protein.

• DOI: 10.1016/j.jnutbio.2018.09.025
• 发表时间: 2019
• 期刊: The Journal of nutritional biochemistry
• 作者: S. Saussenthaler;M. Ouni;C. Baumeier;K. Schwerbel;P. Gottmann;S. Christmann;T. Laeger;A. Schürmann

FGF21, not GCN2, influences bone morphology due to dietary protein restrictions

• DOI: 10.1016/j.bonr.2019.100241
• 发表时间: 2019-12
• 期刊: Bone Reports
• 影响因子: 2.5
• 作者: M. McNulty;Brad A. Goupil;Diana C. Albarado;T. Castaño-Martínez;Thomas H. Ambrosi;Š. Puh;T. Schulz

FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism

• DOI: 10.1016/j.celrep.2019.05.022
• 发表时间: 2019-06-04
• 期刊: CELL REPORTS
• 影响因子: 8.8
• 作者: Hill, Cristal M.;Laeger, Thomas;Morrison, Christopher D.
• 通讯作者: Morrison, Christopher D.

Methionine restriction prevents onset of type 2 diabetes in NZO mice

• DOI: 10.1096/fj.201900150r
• 发表时间: 2019-06-01
• 期刊: FASEB JOURNAL
• 影响因子: 4.8
• 作者: Castano-Martinez, Teresa;Schumacher, Fabian;Laeger, Thomas
• 通讯作者: Laeger, Thomas