Cooperative Action of SNARE Peptides in Fusion (C06*)

SNARE 肽在融合中的协同作用 (C06*)

• 批准号: 340445175
• 金额: --
• 依托单位: Professur Computational Biology
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/340445175?language=en
• 关键词: Cooperative; Action; SNARE; Peptides; Fusion

SNARE peptides act cooperatively during synaptic vesicle fusion. It has previously been suggested that oligomerization of SNARE complexes, which is required for cooperative action in fusion is mediated by interactions between their transmembrane domains (TMDs) and further tuned by interactions with the lipid environment. In this project, the oligomerization of SNARE TMD peptides, their interaction with the lipid surrounding, and the peptide-induced membrane curvature and its influence on membrane fusion will be studied using molecular dynamics simulations.

SNARE肽在突触囊泡融合过程中协同作用。先前的研究表明，SNARE复合物的寡聚化是融合中协同作用所必需的，它是由它们的跨膜结构域（TMDs）之间的相互作用介导的，并通过与脂质环境的相互作用进一步调节。在本项目中，将利用分子动力学模拟研究SNARE TMD肽的寡聚化、与脂质周围的相互作用、肽诱导的膜曲率及其对膜融合的影响。