Cooperative Action of SNARE Peptides in Fusion (C06*)

SNARE肽在突触囊泡融合过程中协同作用。以前已经提出，SNARE复合物的寡聚化，这是需要在融合中的协同作用是由它们的跨膜结构域（TMD）之间的相互作用介导的，并进一步调整与脂质环境的相互作用。在这个项目中，SNARE TMD肽的寡聚化，它们与脂质周围的相互作用，肽诱导的膜曲率及其对膜融合的影响将使用分子动力学模拟进行研究。

SNARE peptides act cooperatively during synaptic vesicle fusion. It has previously been suggested that oligomerization of SNARE complexes, which is required for cooperative action in fusion is mediated by interactions between their transmembrane domains (TMDs) and further tuned by interactions with the lipid environment. In this project, the oligomerization of SNARE TMD peptides, their interaction with the lipid surrounding, and the peptide-induced membrane curvature and its influence on membrane fusion will be studied using molecular dynamics simulations.