Functional roles of intracellular muscarinic acetylcholine receptors in vivo

细胞内毒蕈碱乙酰胆碱受体在体内的功能作用

• 批准号: 19K07117
• 负责人: UWADA Junsuke
• 金额: $ 2.83万
• 依托单位: Kanazawa Medical University (2021)Asahikawa Medical College (2019-2020)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K07117/
• 关键词: ムスカリン受容体; アセチルコリン; トランスポーター; 細胞内受容体; GPCR; acetylcholine; MAP kinase; シグナル情報伝達系

项目成果

p38 MAPK is directly inhibited by PNU-120596, a positive allosteric modulator ofα7 nicotinic acetylcholine receptor.

p38 MAPK 直接被 PNU-120596 抑制，PNU-120596 是 α7 烟碱乙酰胆碱受体的正变构调节剂。

• 发表时间: 2021
• 作者: Yazawa Takashi;Imamichi Yoshitaka;Yuhki Koh‐ichi;Uwada Junsuke;Mikami Daisuke;Shimada Masayuki;Miyamoto Kaoru;Kitano Takeshi;Takahashi Satoru;Sekiguchi Toshio;Suzuki Nobuo;Rafiqul Islam Khan Md.;Ushikubi Fumitaka;Umezawa Akihiro;Taniguchi Takanobu;宇和田淳介
• 通讯作者: 宇和田淳介

11-Ketotestosterone is a major androgen produced in porcine adrenal glands and testes

11-酮睾酮是猪肾上腺和睾丸中产生的主要雄激素

• DOI: 10.1016/j.jsbmb.2021.105847
• 发表时间: 2021
• 期刊: The Journal of Steroid Biochemistry and Molecular Biology
• 作者: Yazawa Takashi;Sato Takahiro;Nemoto Takahiro;Nagata Sayaka;Imamichi Yoshitaka;Kitano Takeshi;Sekiguchi Toshio;Uwada Junsuke;Islam Mohammad Sayful;Mikami Daisuke;Nakajima Ikuyo;Takahashi Satoru;Khan Md. Rafiqul Islam;Suzuki Nobuo;Umezawa Akihiro;Ida Takano
• 通讯作者: Ida Takano

Evaluation of radiolabeled acetylcholine synthesis and release in rat striatum

• DOI: 10.1111/jnc.15556
• 发表时间: 2021-12-17
• 期刊: JOURNAL OF NEUROCHEMISTRY
• 影响因子: 4.7
• 作者: Muramatsu, Ikunobu;Uwada, Junsuke;Masuoka, Takayoshi
• 通讯作者: Masuoka, Takayoshi

Evaluation of 17β-hydroxysteroid dehydrogenase activity using androgen receptor-mediated transactivation

使用雄激素受体介导的反式激活评估 17β-羟基类固醇脱氢酶活性

• DOI: 10.1016/j.jsbmb.2019.105493
• 发表时间: 2020
• 期刊: The Journal of Steroid Biochemistry and Molecular Biology
• 作者: Yazawa Takashi;Imamichi Yoshitaka;Uwada Junsuke;Sekiguchi Toshio;Mikami Daisuke;Kitano Takeshi;Ida Takanori;Sato Takahiro;Nemoto Takahiro;Nagata Sayaka;Islam Khan Md. Rafiqul;Takahashi Satoru;Ushikubi Fumitaka;Suzuki Nobuo;Umezawa Akihiro;Taniguchi Takano
• 通讯作者: Taniguchi Takano

Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways

• DOI: 10.1016/j.bbalip.2020.158666
• 发表时间: 2020-06-01
• 期刊: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
• 影响因子: 4.8
• 作者: Mikami, Daisuke;Kobayashi, Mamiko;Iwano, Masayuki
• 通讯作者: Iwano, Masayuki