Catalytic, Asymmetric Halogenations mediated by hypervalent Iodanes

高价碘介导的催化不对称卤化

• 批准号: 344007829
• 负责人: Professorin Dr. Tanja Gulder
• 金额: --
• 依托单位: Institut für Organische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/344007829?language=en
• 关键词: Catalytic; Asymmetric; Halogenations; mediated; hypervalent

Carbon-halogen bonds constitute a privileged structural motif that often significantly influence the unique properties of organic molecules. Despite the tremendous utility of halogenated compounds, methods for the selective formation of such C,X bonds still constitute a major challenge. Hypervalent iodanes have lately proven to be valuable tools for the bromination and chlorination of alkenes. They are not only a metal-free, mild alternative to conventional halogenation reagents, but also offer the opportunity to explore novel and fascinating reactivities and thereby open new structural space within halogenation chemistry. Application of this promising hypervalent iodine chemistry in asymmetric chlorinations and brominations is thus a rewarding goal that will be addressed within the project by combining the advantages of hypervalent iodanes and chiral organocatalysts.

碳-卤键是有机分子的一种特殊结构，对有机分子的性质有着重要的影响。尽管卤代化合物具有巨大的用途，但选择性形成这种C，X键的方法仍然构成主要挑战。高价碘烷最近被证明是烯烃溴化和氯化的有价值的工具。它们不仅是传统卤化试剂的不含金属的温和替代品，而且还提供了探索新颖和迷人的反应性的机会，从而在卤化化学中开辟了新的结构空间。因此，这种有前途的高价碘化学在不对称氯化和溴化中的应用是一个有价值的目标，将在该项目中通过结合高价碘烷和手性有机催化剂的优点来解决。