Interactions of Insulin-like Growth Factors and their Binding Proteins with Vitronectin: a structural basis for antagonist design and development

胰岛素样生长因子及其结合蛋白与玻连蛋白的相互作用：拮抗剂设计和开发的结构基础

• 批准号: LP0776825
• 负责人: Prof John Wallace
• 金额: $ 14.05万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-15 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0776825
• 关键词: Interactions; Insulin; like; Growth; Factors

Tissue Therapies Ltd has shown that a patented combination of three biosynthetic molecules, VitroGroR, can promote tissue repair effectively. This project will use biophysical and biochemical techniques to investigate precisely how these molecules interact, and hence provide a rational basis for future developments and improvements of this exciting new therapeutic strategy. Conversely, this information would also facilitate the development of antagonists to VitroGroR complexes would provide novel opportunities to treat diseases such as cancer and atherosclerosis that involve excessive production of its component molecules.

Tissue Therapies Ltd已经证明，三种生物合成分子的专利组合VitroGroR可以有效促进组织修复。 该项目将使用生物物理和生物化学技术来精确研究这些分子如何相互作用，从而为这种令人兴奋的新治疗策略的未来发展和改进提供合理的基础。 相反，这一信息也将促进VitroGroR复合物拮抗剂的开发，将为治疗涉及其组分分子过量产生的疾病如癌症和动脉粥样硬化提供新的机会。