New Insights into the Structure and Function of Pyruvate Carboxylase

对丙酮酸羧化酶结构和功能的新见解

• 批准号: DP0988153
• 负责人: Prof John Wallace
• 金额: $ 7.48万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0988153
• 关键词: New; Insights; into; Structure; Function

Pyruvate carboxylase plays an essential roles in insulin secretion by pancreatic islets and in normal brain function, but excess expression of this enzyme in liver and adipose tissue is associated with diabetes and obesity. Understanding the function of each structural feature in the reaction mechanism of an enzyme is essential to designing safe and effective pharmaceuticals that are required to modulate its activity. This project, which will use cutting edge techniques in an experimental model, seeks to characterise this important enzyme's function so that better treatments can be developed in future for diabetes and obesity.

丙酮酸羧化酶在胰岛分泌胰岛素和正常脑功能中起重要作用，但该酶在肝脏和脂肪组织中的过度表达与糖尿病和肥胖症有关。 了解酶反应机制中每个结构特征的功能对于设计调节其活性所需的安全有效的药物至关重要。 该项目将在实验模型中使用尖端技术，旨在验证这种重要酶的功能，以便将来可以开发出更好的糖尿病和肥胖症治疗方法。