HIL-Lung - Hardware-in-the-Loop simulation environment for artificial lungs

HIL-Lung - 人工肺的硬件在环仿真环境

• 批准号: 347367258
• 负责人: Privatdozent Dr. Rüdger Kopp
• 金额: --
• 依托单位: Klinik für Operative Intensivmedizin und Intermediate Care
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/347367258?language=en
• 关键词: HIL; Lung; Hardware; Loop; simulation

HiL-Lung - Hardware-in-the-Loop simulation environment for artificial lungsThis project aims at modelling the interaction between new implantable lung devices and the circulation and aims to establish a physical test environment for such new devices. Based on previous experiences in the field, we propose to use object-oriented modelling which seems is especially suitable to model the dynamics of gas exchange and the hydraulic properties of the circulation in real time. A physical demonstrator shall be set up offering physical connectors to any device under test (dut). This hardware-in-the-loop (HIL) test stand will provide a proper hydraulic interface (similar pressures, pulsatile perfusion, etc.) and will hence allow an automatic characterization of any newly developed artificial lung, either biological, technical or hybrid in nature, provided that the physical connections fit. Next to water, blood is intended to be used in order to have a realistic environment and to allow investigation of gas exchange and hemocompatibility issues. If done right, the implant under test will not notice that the HIL environment is any different from a living organism. Next to using simulated flow and pressure profiles, the HIL test stand also allows to repetitively use measured data obtained in earlier animal trials. As this can be done repetitively without the need for additional animal trials, this HIL test stand will most likely reduce the total number of necessary animal trials. Finally, the HIL test stand also allows to investigate questions regarding safety, robustness, automation and control as well as monitoring in an early stage.

HiL-Lung -人工肺的硬件在环仿真环境该项目旨在模拟新型植入式肺设备与循环之间的相互作用，并旨在为此类新设备建立物理测试环境。根据以往的经验，在该领域中，我们建议使用面向对象的建模，这似乎是特别适合的气体交换的动态和水力特性的循环在真实的时间。应建立一个物理演示器，为任何被测设备（dut）提供物理连接器。该硬件在环（HIL）测试台将提供适当的液压接口（类似压力、脉动灌注等）。并且因此将允许自动表征任何新开发的人工肺，无论是生物的、技术的还是混合的，只要物理连接适合。除水外，预期使用血液以获得真实的环境，并允许研究气体交换和血液相容性问题。如果操作正确，受试植入物将不会注意到HIL环境与活生物体有任何不同。除了使用模拟流量和压力曲线外，HIL测试台还允许重复使用早期动物试验中获得的测量数据。由于这可以重复进行而无需额外的动物试验，因此该HIL试验台很可能会减少必要的动物试验总数。最后，HIL测试台还允许在早期阶段调查有关安全性、鲁棒性、自动化和控制以及监控的问题。