Reliability and variability of visual acuity assessments

视力评估的可靠性和可变性

• 批准号: 35225420
• 负责人: Professor Dr. Michael Bach
• 金额: --
• 依托单位: Klinik für Augenheilkunde
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2011-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/35225420?language=en
• 关键词: Reliability; variability; visual; acuity; assessments

Estimation of visual acuity is fundamental to any ophthalmological assessment, and with new treatment options, such as retinal prostheses and gene therapy, the accurate monitoring of acuity is becoming increasingly important. However, acuity measurements are not as straightforward as the first glance suggests. Studies in other areas of visual performance have demonstrated that the outcome of a measurement depends substantially on factors beyond the physiological parameter to be assessed. Many of these factors are related to the decision process in individual subjects during identification of the optotypes. Other issues include the willingness of the patient to perform a test (potential malingering), and the ability of an acuity test to predict real-life performance of a patient depending on the specific disease. We propose a series of experiments that will shed light on these issues with the aim of understanding and ultimately reducing sources of variability in acuity assessments. One fork of the project will assess discrepancies between VEP-based and psychophysical acuity estimates that occur in certain cases, e.g. in amblyopia. In a second fork we will evaluate applications of cognitive event-related potentials in patients. The third fork will focus on the factors determining the outcome of the subjective acuity estimates, which are still the gold standard.

视敏度的估计是任何眼科评估的基础，并且随着新的治疗选择，例如视网膜假体和基因治疗，对视敏度的准确监测变得越来越重要。然而，敏锐度测量并不像第一眼所看到的那样简单。在视觉性能的其他领域的研究表明，测量的结果在很大程度上取决于要评估的生理参数之外的因素。这些因素中的许多与个体受试者在识别视标期间的决策过程有关。其他问题包括患者进行测试的意愿（潜在的诈病），以及根据特定疾病预测患者现实生活表现的能力。我们提出了一系列的实验，将阐明这些问题的理解，并最终减少敏锐度评估的变异性来源的目的。该项目的一个分支将评估在某些情况下发生的基于VEP和心理物理敏锐度估计之间的差异，例如弱视。在第二个分叉中，我们将评估认知事件相关电位在患者中的应用。第三个分叉将集中在决定主观敏锐度估计结果的因素上，这仍然是黄金标准。