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Objective Assessment of Visual Functions

视觉功能的客观评估

基本信息

批准号：
223010076
负责人：
Professor Dr. Michael Bach
金额：
--
依托单位：
Klinik für Augenheilkunde
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2012
资助国家：
德国
起止时间：
2011-12-31 至 2015-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/223010076?language=en
关键词：
Objective Assessment Visual Functions

项目摘要

The objective assessment of visual function, namely visual acuity, is becoming increasingly important, often for medico-legal reasons. In an earlier project we developed an appropriate technique yielding an acuity estimate with an associated confidence interval. This is in routine use and has been licensed by industry. Experience has shown that we need to make two major improvements:The first is to solve an emergent methodological problem: previous visual display units employed the cathode-ray principle. They are no longer being produced, as LCDs have taken their place. While useful for most applications, LCDs have marked luminance artifacts, which render them quite unsuitable for estimating visual function. We hope to solve this problem with new stimulation regimes that disambiguate artifactual luminance responses from pattern responses in the Fourier domain.The other problem is a physiological one: the so-called notch, a marked amplitude loss in an intermediate spatial frequency region; this occurs in about 50% of all subjects. Its physiological basis is not understood. We hypothesize this to be due to the destructive superposition either of local dipole responses from an extent of cortical sources, or the temporal overlap of response components with opposite polarity. Using multichannel recordings (never applied to this question before) and higher-order Laplace derivations in combination with a wide range of visual field extents and temporal presentation rate, we are aiming at two goals: (1) to improve our understanding of the physiological basis of the notch, and (2) to arrive at an optimized stimulation and recording paradigm applicable to routine estimations of visual function in all patients.

视觉功能的客观评估，即视觉敏锐度，正变得越来越重要，通常是出于医学和法律方面的原因。在一个较早的项目中，我们开发了一种适当的技术来产生具有相关可信区间的视力估计。这是在常规使用，并已获得行业许可。经验表明，我们需要做两个主要的改进：第一个是解决一个紧迫的方法学问题：以前的视觉显示单元采用阴极射线原理。它们不再生产，因为LCD已经取代了它们的位置。虽然LCD对大多数应用很有用，但它有明显的亮度伪影，这使得它们非常不适合估计视觉功能。我们希望通过新的刺激机制来解决这个问题，这种刺激机制可以消除傅里叶域中人工亮度响应和模式响应的歧义。另一个问题是生理问题：所谓的凹槽，在中间空间频率区域发生显著的幅度损失；大约50%的受试者会发生这种情况。其生理基础尚不清楚。我们假设这是由于来自一定范围的大脑皮层的局部偶极响应的破坏性叠加，或者是具有相反极性的响应分量的时间重叠。使用多通道记录(以前从未应用于这个问题)和高阶拉普拉斯导数，结合广泛的视野范围和时间呈现速率，我们的目标有两个：(1)提高我们对切迹的生理基础的理解，(2)得出一种适用于所有患者的常规视功能评估的优化刺激和记录范式。