Characterising post-translational modifications in bacterial proteins

表征细菌蛋白质的翻译后修饰

• 批准号: DP0664922
• 负责人: Prof Stuart Cordwell
• 金额: $ 16.48万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-03-31 至 2009-03-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0664922
• 关键词: Characterising; post; translational; modifications; bacterial

This project represents the first global attempt to characterize post-translational modifications in bacterial proteins using the tools of proteomics. Modifications to proteins are key elements in altering their function. In bacteria, modifications are important in cell-cell adhesion, signalling and triggering of the immune response. Characterisation of modified proteins and their sites of modification represents an opportunity to understand how bacterial cell populations communicate in the environment, as well as aid in understanding pathogenesis in medical, veterinary and food-borne pathogens. Therefore, improved vaccine targets and therapeutics, as well as method-based products, may be generated by this project.

该项目代表了全球首次尝试使用蛋白质组学工具来表征细菌蛋白质的翻译后修饰。蛋白质的修饰是改变其功能的关键因素。在细菌中，修饰在细胞-细胞粘附、信号传导和触发免疫反应中很重要。修饰蛋白及其修饰位点的表征为了解细菌细胞群如何在环境中交流提供了机会，也有助于了解医学、兽医和食源性病原体的发病机制。因此，该项目可能会产生改进的疫苗靶点和治疗方法以及基于方法的产品。