Characterising post-translational modifications in bacterial proteins

该项目代表了利用蛋白质组学工具对细菌蛋白质翻译后修饰进行表征的第一次全球尝试。蛋白质的修饰是改变其功能的关键因素。在细菌中，修饰在细胞间黏附、发出信号和触发免疫反应方面很重要。修饰蛋白质及其修饰部位的特征提供了一个了解细菌细胞群如何在环境中交流的机会，并有助于了解医学、兽医和食源性病原体的发病机制。因此，该项目可能产生改进的疫苗靶点和疗法以及基于方法的产品。

This project represents the first global attempt to characterize post-translational modifications in bacterial proteins using the tools of proteomics. Modifications to proteins are key elements in altering their function. In bacteria, modifications are important in cell-cell adhesion, signalling and triggering of the immune response. Characterisation of modified proteins and their sites of modification represents an opportunity to understand how bacterial cell populations communicate in the environment, as well as aid in understanding pathogenesis in medical, veterinary and food-borne pathogens. Therefore, improved vaccine targets and therapeutics, as well as method-based products, may be generated by this project.