The role of N-linked protein glycosylation in Campylobacter jejuni pathogenesis

N联蛋白糖基化在空肠弯曲杆菌发病机制中的作用

• 批准号: nhmrc : 1106878
• 负责人: Prof Stuart Cordwell
• 金额: $ 52.12万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-n-linked-jejuni-pathogenesis/662940
• 关键词: role; linked; protein; glycosylation; Campylobacter

Protein glycosylation is crucial in enabling C. jejuni to colonize poultry, which is the most common route to human infection. The roles played by this modification remain almost completely unknown yet are likely to be multi-factorial. This project will determine the function of glycosylation and thus lead to eventual interventions aimed at reducing the organism in poultry for human consumption.

蛋白质糖基化是空肠弯曲菌在家禽中定植的关键，而家禽是人类感染的最常见途径。这种修改所扮演的角色仍然几乎完全未知，但很可能是多因素的。该项目将确定糖基化的功能，从而导致最终的干预措施，目的是减少供人食用的家禽中的有机体。