KFO 196: Signal Transduction in Adaptive and Maladaptive Cardiac Remodelling

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Chronic heart failure is a rapidly growing health problem in the industrialised countries and represents the most common diagnosis of hospital admission in elderly patients. However, the molecular pathology of chronic heart failure is still incompletely understood and therapeutic options are limited. Similarly, atrial fibrillation is a leading cause of morbidity, the incidence is markedly increased in patients with heart failure and impairs their left ventricular function as well as the clinical outcome. The Clinical Research Unit at the University of Saarland will therefore further characterise the molecular mechanisms of physiologic and pathologic remodelling of the ventricular and atrial myocardium.