KFO 196: Signal Transduction in Adaptive and Maladaptive Cardiac Remodelling

KFO 196：适应性和适应不良心脏重塑中的信号转导

• 批准号: 35635434
• 金额: --
• 依托单位: Klinik und Poliklinik für Kardiologie
• 依托单位国家: 德国
• 项目类别: Clinical Research Units
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/35635434?language=en
• 关键词: KFO; 196; Signal; Transduction; Adaptive

Chronic heart failure is a rapidly growing health problem in the industrialised countries and represents the most common diagnosis of hospital admission in elderly patients. However, the molecular pathology of chronic heart failure is still incompletely understood and therapeutic options are limited. Similarly, atrial fibrillation is a leading cause of morbidity, the incidence is markedly increased in patients with heart failure and impairs their left ventricular function as well as the clinical outcome. The Clinical Research Unit at the University of Saarland will therefore further characterise the molecular mechanisms of physiologic and pathologic remodelling of the ventricular and atrial myocardium.

慢性心力衰竭是工业化国家中迅速增长的健康问题，是老年患者入院时最常见的诊断。然而，慢性心力衰竭的分子病理学仍未完全了解，治疗选择也有限。同样，心房颤动是发病的主要原因，心力衰竭患者的发病率显着增加，并损害其左心室功能和临床结果。因此，萨尔大学的临床研究单位将进一步表征心室和心房心肌生理和病理重塑的分子机制。

项目成果

Effect of Renal Denervation on Neurohumoral Activation Triggering Atrial Fibrillation in Obstructive Sleep Apnea

• DOI: 10.1161/hypertensionaha.113.01728
• 发表时间: 2013-10-01
• 期刊: HYPERTENSION
• 影响因子: 8.3
• 作者: Linz, Dominik;Hohl, Mathias;Boehm, Michael
• 通讯作者: Boehm, Michael

Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study

• DOI: 10.1016/s0140-6736(13)62192-3
• 发表时间: 2014-02-15
• 期刊: LANCET
• 影响因子: 168.9
• 作者: Krum, Henry;Schlaich, Markus P.;Esler, Murray D.
• 通讯作者: Esler, Murray D.