Predicting heterosis in F1 hybrids from parental DNA methylomes (A13)

根据亲本 DNA 甲基化预测 F1 杂种的杂种优势 (A13)

• 批准号: 357238547
• 金额: --
• 依托单位: Professur für Populations-Epigenetik und Epigenomik
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/357238547?language=en
• 关键词: Predicting; heterosis; F1; hybrids; parental

Despite the importance and wide exploitation of heterosis in commercial crop breeding, the molecular mechanisms behind this phenomenon are not well understood. There is growing evidence that, beside genetic, also epigenetic factors contribute to heterosis. In this project, we perform high-throughput phenotypic and epigenomic analyses of a large panel of Arabidopsis thaliana epiHybrids, which were derived from isogenic but epigenetically divergent parents. Our aim is to test whether parental DNA methylation states determine hybrid performance as well as the functional remodelling of hybrid genomes, independently of DNA sequence variation.

尽管杂种优势在经济作物育种中的重要性和广泛利用，但这一现象背后的分子机制尚未得到很好的理解。越来越多的证据表明，除了遗传因素外，表观遗传因素也有助于杂种优势。在这个项目中，我们进行高通量的表型和表观基因组分析的一个大面板的拟南芥epiHybrids，这是来自同基因，但表观遗传分歧的父母。 我们的目的是测试父母的DNA甲基化状态是否决定杂交性能以及杂交基因组的功能重塑，独立于DNA序列变异。