Modular assembly, plasma membrane targeting and regulation of KCNQ (Kv7) K+ channels (C04)

KCNQ (Kv7) K 通道 (C04) 的模块化组装、质膜靶向和调节

• 批准号: 35799680
• 金额: --
• 依托单位: Institut für Chemie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/35799680?language=en
• 关键词: Modular; assembly; plasma; membrane; targeting

Subunit-specific assembly of human KCNQ (Kv7) channels is determined by a carboxy-terminal domain, which contains two coiled-coil sequences. This project aims at the clarification of molecular determinants within the KCNQ C-termini, which drive the modular assembly of KCNQ subunits into functional channels, determine the efficiency of transport of channel modules to the plasma membrane, and mediate interactions with regulatory proteins. Analysis guided by the modular concept will resolve the complexity of KCNQ channel assembly and regulation in excitable cells, with implications on K+ channel biophysics to neurophysiology.

人KCNQ（KV7）通道的亚基特异性组装由羧基末端结构域确定，该结构域包含两个盘绕螺旋序列。该项目的目的是阐明KCNQ C-termini中的分子决定因素，该项目将KCNQ亚基的模块化组装到功能通道中，确定通道模块向质膜传输的效率，并介导与调节蛋白的相互作用。由模块化概念指导的分析将解决可激发细胞中KCNQ通道组装和调节的复杂性，对K+通道生物物理学对神经生理学的影响。