The inhibition of muscle disuse atrophy in burrowing frogs

穴居蛙肌肉废用性萎缩的抑制

• 批准号: DP0666256
• 负责人: Prof Craig Franklin
• 金额: $ 59.17万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-03-13 至 2011-03-12
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0666256
• 关键词: inhibition; muscle; disuse; atrophy; burrowing

Prolonged muscle disuse, as a consequence of limb immobilisation, extended bed-rest or space travel, can lead to pathological changes resulting in muscle wasting. By examining a unique Australian frog that burrows underground and remains immobile for 9-12 months, and which shows no muscle wasting, we will significantly advance our understanding of the physiological mechanisms that inhibit muscle atrophy. Benefits of conducting this research will include: - understanding the role of antioxidants and endogenous opioids in reducing muscle wasting - training of postgraduate students - stimulating collaboration between The University of Queensland and CSIRO Livestock Industries.

由于肢体固定、长时间卧床休息或太空旅行，肌肉长期不使用可导致肌肉萎缩的病理变化。通过研究一种独特的澳大利亚青蛙，这种青蛙在地下挖洞，一动不动9-12个月，没有肌肉萎缩，我们将大大提高我们对抑制肌肉萎缩的生理机制的理解。