The inhibition of muscle disuse atrophy in burrowing frogs

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Prolonged muscle disuse, as a consequence of limb immobilisation, extended bed-rest or space travel, can lead to pathological changes resulting in muscle wasting. By examining a unique Australian frog that burrows underground and remains immobile for 9-12 months, and which shows no muscle wasting, we will significantly advance our understanding of the physiological mechanisms that inhibit muscle atrophy. Benefits of conducting this research will include: - understanding the role of antioxidants and endogenous opioids in reducing muscle wasting - training of postgraduate students - stimulating collaboration between The University of Queensland and CSIRO Livestock Industries.