Control of extracellular matrix production required for cartilage tissue regeneration

控制软骨组织再生所需的细胞外基质产生

• 批准号: 18K06248
• 负责人: Shinomura Tamayuki
• 金额: $ 2.83万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K06248/
• 关键词: 軟骨; 再生; 転写制御; II型コラーゲン; アグリカン; 転写因子; エンハンサー; 軟骨細胞; エピゲノム修飾

项目成果

Expression of type II collagen and aggrecan genes is regulated through the distinct epigenetic modification of multiple enhancer elements

II 型胶原蛋白和聚集蛋白聚糖基因的表达通过多个增强子元件的独特表观遗传修饰进行调节

• 发表时间: 2019
• 作者: 北谷育子;手塚茜;長谷川恵理;Jay Z. Parrish;榎本和生;Fukuyama M;Tamayuki Shinomura
• 通讯作者: Tamayuki Shinomura

Gene expression of type II collagen is regulated by direct interaction with Kruppel-like factor 4 and AT-rich interactive domain 5B

• DOI: 10.1016/j.gene.2020.145381
• 发表时间: 2021-01-11
• 期刊: GENE
• 影响因子: 3.5
• 作者: Zhang，Xiang;Nham，Giang Thi Hien;Shinomura，Tamayuki
• 通讯作者: Shinomura，Tamayuki

Identification of an enhancer-specific transcription factor regulating type II collagen gene expression

调节 II 型胶原蛋白基因表达的增强子特异性转录因子的鉴定

• 发表时间: 2018
• 作者: Zhang Xiang;Nham T.H. Giant;Tamayuki Shinomura
• 通讯作者: Tamayuki Shinomura

Expression of type II collagen and aggrecan genes is regulated through distinct epigenetic modifications of their multiple enhancer elements

• DOI: 10.1016/j.gene.2019.04.034
• 发表时间: 2019-07-01
• 期刊: GENE
• 影响因子: 3.5
• 作者: Giang Thi Hien Nham;Zhang, Xiang;Shinomura, Tamayuki
• 通讯作者: Shinomura, Tamayuki

Suppression of hyaluronan synthesis attenuates the tumorigenicity of low-grade chondrosarcoma

抑制透明质酸合成可减弱低度软骨肉瘤的致瘤性

• DOI: 10.1002/jor.23794
• 发表时间: 2019
• 期刊: Journal of Orthopaedic Research?
• 作者: Hamada Shunsuke;Nishida Yoshihiro;Zhuo Lisheng;Shinomura Tamayuki;Ikuta Kunihiro;Arai Eisuke;Koike Hiroshi;Kimata Koji;Ushida Takahiro;Ishiguro Naoki
• 通讯作者: Ishiguro Naoki