Crosstalk between enteric neurons, immune cells and intestinal flora in the maintenance of intestinal homeostasis

肠道神经元、免疫细胞和肠道菌群之间的串扰在维持肠道稳态中的作用

• 批准号: 18K06951
• 负责人: HATANO Masahiko
• 金额: $ 2.83万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K06951/
• 关键词: 腸管神経; 腸管免疫; 腸内細菌; Hirschsprung病類縁疾患; Ncx KOマウス; 好酸球; 腸内細菌叢; 無菌マウス; Neuromedin U; IL5; IL-5; 腸内フローラ

项目成果

Deletion of Eqtn in mice reduces male fertility and sperm-egg adhesion

• DOI: 10.1530/rep-18-0394
• 发表时间: 2018-12-01
• 期刊: REPRODUCTION
• 影响因子: 3.8
• 作者: Ito, Chizuru;Yamatoya, Kenji;Toshimori, Kiyotaka
• 通讯作者: Toshimori, Kiyotaka

Reciprocal negative regulation between the tumor suppressor protein p53 and B cell CLL/lymphoma 6 (BCL6) via control of caspase-1 expression

• DOI: 10.1074/jbc.ra118.004204
• 发表时间: 2019-01-04
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Kim, Min-Kyeong;Song, Ji-Yang;Hur, Man-Wook
• 通讯作者: Hur, Man-Wook

Essential role of microglial transforming growth factor-β1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-β1

• DOI: 10.1038/s41398-020-0733-x
• 发表时间: 2020-01-27
• 期刊: TRANSLATIONAL PSYCHIATRY
• 影响因子: 6.8
• 作者: Zhang, Kai;Yang, Chun;Hashimoto, Kenji
• 通讯作者: Hashimoto, Kenji

Bcl6 maintains germinal center B cells and regulates memory B cell function

Bcl6 维持生发中心 B 细胞并调节记忆 B 细胞功能

• 发表时间: 2021
• 作者: Qin Fan;Lasa Fujimura;Masahiko Hatano;Akemi Sakamoto
• 通讯作者: Akemi Sakamoto

Critical roles of enteric neurons in intestinal microbiota and barrier function

肠神经元在肠道微生物群和屏障功能中的关键作用

• 发表时间: 2018
• 作者: Kurihara Kazuki;Homma Takujiro;Kobayashi Sho;Shichiri Mototada;Fujiwara Hiroki;Fujii Satoshi;Yamada Ken-ichi;Nakane Masaki;Kawamae Kaneyuki;Fujii Junichi;Masahiko Hatano
• 通讯作者: Masahiko Hatano