Parasite virulence: the role of activation and suppression of P2X7 receptors

寄生虫毒力：P2X7 受体激活和抑制的作用

• 批准号: DP0666515
• 负责人: Prof Nicholas Smith
• 金额: $ 15.24万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-02-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0666515
• 关键词: Parasite; virulence; role; activation; suppression

Toxoplasmosis and leishmaniasis pose a threat to the health and well-being of the Australian human and animal populations. Around 6-8 million Australians are infected with Toxoplasma, a parasite that can cause severe problems in immunosuppressed individuals and birth defects and miscarriage in pregnant women with a primary infection. Toxoplasmosis is also the main cause of abortion and stillbirth in Australian sheep. Leishmaniasis, recently found in Australia, is a risk for overseas travellers, livestock and wildlife. This research will provide an understanding of what makes these parasites successful, paving the way for development of novel drugs to combat these chronic diseases.

弓形虫病和利什曼病对澳大利亚人类和动物种群的健康和福祉构成威胁。大约有 6-800 万澳大利亚人感染了弓形虫，这种寄生虫可能会导致免疫抑制个体出现严重问题，并导致原发感染的孕妇出现出生缺陷和流产。弓形虫病也是澳大利亚绵羊流产和死产的主要原因。最近在澳大利亚发现的利什曼病对海外旅行者、牲畜和野生动物构成风险。这项研究将有助于了解这些寄生虫成功的原因，为开发对抗这些慢性疾病的新药铺平道路。