The molecular basis for oocyst and cyst wall formation in apicomplexan parasites

顶复门寄生虫卵囊和囊壁形成的分子基础

• 批准号: LP0454145
• 负责人: Prof Nicholas Smith
• 金额: $ 28.2万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-08-27 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0454145
• 关键词: molecular; basis; oocyst; cyst; wall

Apicomplexan parasites such as Eimeria, Neospora, Toxoplasma and Plasmodium are single celled organisms - protozoa - that cause some of the most serious infectious diseases of livestock and humans ever known. Transmission of these parasites is dependent on their ability to encase themselves in protective structures known as oocyst or cyst walls. These walls are resistant to harsh environmental conditions, chemicals and attack by the immune system. We will discover and characterise the molecular basis for cyst wall formation. This fundamental knowledge will be the building block for new, highly specific drugs and vaccines to control these extremely important pathogens.

顶复门寄生虫如艾美球虫、新孢子虫、弓形虫和疟原虫是单细胞生物体-原生动物-其引起迄今已知的牲畜和人类的一些最严重的传染病。这些寄生虫的传播依赖于它们将自己包裹在被称为卵囊或囊壁的保护结构中的能力。这些墙可以抵抗恶劣的环境条件，化学品和免疫系统的攻击。我们将发现并阐明囊壁形成的分子基础。这些基础知识将成为控制这些极其重要的病原体的新型高度特异性药物和疫苗的基础。