Basic research on developing new anti-HBV therapeutic strategy for cccDNA elimination by DOCK11 knockdown in HBV infected hepatocytes

通过敲低 HBV 感染肝细胞中的 DOCK11 消除 cccDNA 开发新的抗 HBV 治疗策略的基础研究

• 批准号: 18K07966
• 负责人: LI YING-YI
• 金额: $ 2.91万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K07966/
• 关键词: HBV; cccDNA; DOCK11; Retrograde trafficking; Golgi; AGAP2; ARF1; antivirus therapy; Hepatitis B virus; Dock11; infection; cccDNA stability; retrograde trafficking; assembly of HBV DNA

项目成果

DOCK11 might be a candidate druggable target for HBV cure

DOCK11可能是治疗乙型肝炎的候选药物靶点

• 发表时间: 2021
• 作者: Ying-Yi Li;Masao Honda;and Shuichi Kaneko
• 通讯作者: and Shuichi Kaneko

mTORC2-Akt phosphorylation is associsted with Notch signaling activation by nucleotide analogues but not nucleoside analogues for chronic HBV infection

mTORC2-Akt 磷酸化与慢性 HBV 感染的核苷酸类似物而非核苷类似物的 Notch 信号传导激活相关

• 发表时间: 2018
• 作者: Kazunori Kawaguchi;Zijing Wang;Masao Honda;takayoshi shirasaki;Hikari Okada;Ying-Yi Li;Kazuhisa Murai;Kouki Nio;Tetsuro Shimakami;Taro Yamashita;Shinichi Hashimoto;Kazuyuki kuroki;Seishi Murakami;Shuichi Kaneko
• 通讯作者: Shuichi Kaneko

A liver-derived secretory protein, LECT2, restores the impaired plasmacytoid dendritic cells function by HBV and protects hepatocytes against HBV infection

肝源性分泌蛋白 LECT2 可恢复 HBV 受损的浆细胞样树突状细胞功能，并保护肝细胞免受 HBV 感染

• 发表时间: 2018
• 作者: Takayoshi shirasaki;Masao Honda;Tetsuro Shimakami;Kazunori Kawaguchi;Ying-Yi LI;Kouki Nio;Taro Yamashita;Shuichi Kaneko
• 通讯作者: Shuichi Kaneko