Neurotrophic Active Natural Products: Total Synthesis and Biological Evaluation of Neovibsanins A and B, and Analogues

神经营养活性天然产物：Neovibsanins A 和 B 以及类似物的全合成和生物学评价

• 批准号: DP0666855
• 负责人: Prof Craig Williams
• 金额: $ 18.02万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0666855
• 关键词: Neurotrophic; Active; Natural; Products; Total

New chemical entities (drug candidates) that promote neurite outgrowth have significant ramifications to mankind as they have real potential to repair damaged, or grow replacement, nerve cells affected by neuro and central nervous system (CNS) degenerative disease (e.g. Alzhiemer's, Parkinson's, Huntington's etc). This scientific endeavour will reveal new drug like molecules for potential biological and clinical application, thereby assisting a substantial proportion of Australians suffering from these debilitating diseases.

促进神经突起生长的新化学实体(候选药物)对人类具有重大影响，因为它们具有修复受损神经细胞或培育替代细胞的真正潜力，这些神经细胞受到神经和中枢神经系统(CNS)退行性疾病(如阿尔茨海默氏症、帕金森氏症、亨廷顿氏症等)的影响。这项科学努力将揭示潜在的生物和临床应用的新药类分子，从而帮助相当大比例的澳大利亚人患有这些令人衰弱的疾病。