Modular Synthesis of Organic Cage Compounds through Dynamic Covalent Chemistry

该项目的目的是基于合理和可预测的设计方法，模块化合成具有不同大小，形状和功能程度的共价有机笼状化合物。基于分子工具箱，人们可以通过各种单体子组件的适当组合轻松访问集成架构。由于其明确的拓扑结构和刚性结构，这些笼子允许不同功能的精确空间安排。作为实现这些目标的主要合成工具，我们希望利用小分子前体的适当功能化以及组装的笼的合成后修饰。在笼腔内的反应位置的实现导致了量身定制的协调环境的形成，这应该用于与合适的客体分子的特定相互作用或模板辅助笼的组装。此外，反应位点的外面体附着可以通过更好地控制固体状态下的三维排列而导致单体笼单元的特异性交联。

Aim of this project is the modular synthesis of covalent organic cage compounds with varying size, shape and degree of functionality based on a rational and predictable design approach. Based on a molecular tool box, one get easy access to integrative architectures by means of suitable combinations of various monomeric subcomponents. Due to their defined topology and rigid structures, these cages allow for a precise spatial arrangement of different functionalities. As the main synthetic tools to achieve these aims, we want to utilize both appropriate functionalization of the small-molecule precursors as well as post-synthetic modifications of the assembled cages. The implementation of reactive positions within the cage cavities leads to the formation of tailor-made coordination environments, which should be exploited for specific interactions with suitable guest molecules or the template-assisted assembly of the cages. Furthermore, the exohedral attachment of reactive sites can lead to the specific cross-linking of monomeric cage units though facilitating a better control over the three-dimensional arrangement in the solid state.