Molecular mechanisms of cellular functional interaction in the trigeminal ganglion underlying ectopic persistent pain associated with tooth pulp inflammation

牙髓炎症相关异位持续性疼痛三叉神经节细胞功能相互作用的分子机制

• 批准号: 18K17077
• 负责人: OHARA KINUYO
• 金额: $ 2.66万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K17077/
• 关键词: 歯髄炎; 異所性疼痛異常; 異所性疼痛; TLR4; 関連痛; 三叉神経節細胞; NFkB; MAPキナーゼ

项目成果

Spinal Cord Microglial Phenotypic Changes Following Sciatic Nerve Crush in CD137LKO Mice

CD137LKO 小鼠坐骨神经挤压后脊髓小胶质细胞表型变化

• 发表时间: 2019
• 作者: David Nicholas;Kinuyo Ohara;Ling Cao
• 通讯作者: Ling Cao

Involvement of Satellite Cell Activation via Nitric Oxide Signaling in Ectopic Orofacial Hypersensitivity

• DOI: 10.3390/ijms21041252
• 发表时间: 2020-02
• 期刊: International Journal of Molecular Sciences
• 影响因子: 5.6
• 作者: Jun Lee;Kinuyo Ohara;M. Shinoda;Yoshinori Hayashi;Asako Kubo;Shiori Sugawara;Sayaka Asano;Kumi Soma;Kohei Kanno;Masatoshi Ando;R. Koyama;Yuki Kimura;Kousuke Sakanashi;T. Iinuma;K. Iwata

Upregulation of calcitonin gene-related peptide, neuronal nitric oxide synthase, and phosphorylated extracellular signal-regulated kinase 1/2 in the trigeminal ganglion after bright light stimulation of the eye in rats

大鼠眼睛强光刺激后三叉神经节降钙素基因相关肽、神经元一氧化氮合酶和磷酸化细胞外信号调节激酶1/2的上调

• DOI: 10.2334/josnusd.18-0031
• 发表时间: 2019
• 期刊: Journal of Oral Science
• 影响因子: 1.9
• 作者: Okada S;Saito H;Matsuura Y;Mikuzuki L;Ohara K;Lee J;Iinuma T;Katagiri A *;Iwata K
• 通讯作者: Iwata K

Role of Neuron-Glial Interaction Mediated by IL-1β in Ectopic Tooth Pain

• DOI: 10.1177/0022034517741253
• 发表时间: 2018-04-01
• 期刊: JOURNAL OF DENTAL RESEARCH
• 影响因子: 7.6
• 作者: Komiya, H.;Shimizu, K.;Iwata, K.
• 通讯作者: Iwata, K.