Enantioselective Iron- or Cobalt-Catalyzed Hydrohydroxyalkylation of Butadiene

对映选择性铁或钴催化的丁二烯氢羟烷基化

• 批准号: 375506648
• 负责人: Dr. Johannes Tauber
• 金额: --
• 依托单位: Institut für Organische Chemie und Chemische Biologie
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/375506648?language=en
• 关键词: Enantioselective; Iron; Cobalt; Catalyzed; Hydrohydroxyalkylation

The crotylation of carbonyls is an important process in organic chemistry and enables the access to building blocks for the total synthesis of natural products such as the large and highly important class of polyketides. An enantioselective ruthenium- or iridium-catalyzed hydrohydroxyalkylation of butadiene forming crotylation products was developed in the Krische group which led to a process with perfect atom economy. The current project will involve the transfer of this methodology to inexpensive, less toxic, iron- or cobalt-based catalysts. Thus, a by-product free, atom economical, environmentally benign, valuable method with a high attractivity for industrial applications will be developed.

羰基化是有机化学中的一个重要过程，能够获得天然产物，如大而重要的聚酮类化合物的全合成的基本单元。在Krische基团中开发了一种对映选择性的Ru或Ir催化的丁二烯氢羟烷基化反应，生成了巴豆化产物，这导致了一个具有完美原子经济性的过程。目前的项目将涉及将这一方法转移到价格低廉、毒性较低的铁或钴催化剂上。因此，一种无副产物、原子经济、环境友好、具有高吸引力的工业应用方法将被开发出来。

项目成果

Enantioselective Iridium Catalyzed Phthalide Formation via Internal Redox Allylation of Phthalaldehydes **

• DOI: 10.1002/ange.201712015
• 发表时间: 2018
• 作者: Allylation of Phthalaldehydes;James M Cabrera;Dr. Johannes Tauber;M. Krische