Investigation of chemical mixture effects on children's health in E-waste processing sites

电子废物处理场所化学混合物对儿童健康影响的调查

• 批准号: 19F19113
• 负责人: 中山 祥嗣
• 金额: $ 1.47万
• 依托单位: National Institute for Environmental Studies
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-25 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19F19113/
• 关键词: E-waste; 母乳; ダイオキシン類; 金属; 子ども; ステロイドホルモン

中国内e-waste処理地区における、POPsや難燃剤、金属類等の化学物質複合ばく露の影響について、特に、感受性の高い子ども着目し、臍帯血・血液・尿中ステロイドホルモンをバイオマーカーとして用いて解析した。具体的には、1）e-waste地域における化学物質複合ばく露の実態調査、2）機械学習やベイズ統計解析法を用いた、POPsや難燃剤、金属類等の化学物質複合ばく露が子どものステロイドホルモンおよび精神発達に与える影響の解析、3）母親の化学物質ばく露やステロイドホルモンレベルと、第1子の精神発達との関連の解析及び4）e-wasteリサイクルに対する、従事者や環境への影響を最小限に抑える処理技術の検討を行った。令和2年度の研究で以下研究内容を実施した。1）第三回調査：2020/5-2020/6に生後6ヶ月の子どもから血液5 mL、尿20 mLを採取した。子ども身体発達の測定、母親とその子の質問紙調査。2）第四回調査：2020/11-2020/12に生後12ヶ月の子どもから血液5 mL、尿20 mLを採取した。子ども身体発達の測定、母親とその子の質問紙調査。令和2年度は、以下の研究成果を得た。1）E-waste処理地区の母乳中の金属が対照地区より高いことが判明した。2）E-waste処理地区の周産期の金属ばく露により子どもの身体発達に性差をもたらすことを発見した。

In the e-waste processing area in China, the impact of compound chemical substances such as POPs, flame retardants, metals, etc.に, Sensitivity of high-sensitivity test, Umbilical cord blood, blood, and urine analysis of umbilical cord blood, blood, and urine. Specific details: 1) e-waste regional chemical substance compound status survey, 2) machine learning statistical analysis The method is to use chemical substances such as POPs, flame retardants, metals, etc. to combine them. Analysis of the influence of the mother, 3) Analysis of the relationship between the chemical substance of the mother and the spiritual development of the first son And び4) e-waste waste management technology, environmental protection and environmental impact, minimum limit processing technology, and processing technology. The following research content of the research in Reiwa 2nd year is implemented. 1) The third survey: 5 mL of blood and 20 mL of urine were taken from a child 6 months after birth on 2020/5-2020/6. The child's physical condition was measured, and the mother's mother was questioned by the child. 2) The fourth survey: 5 mL of blood and 20 mL of urine were taken from the child 12 months after birth from 2020/11 to 2020/12. The child's physical condition was measured, and the mother's mother was questioned by the child. In the second year of Reiwa, the following research results were obtained. 1) The metal contained in breast milk in the E-waste treatment area has been found to be high and clear. 2) The E-waste treatment area is a metal that is exposed during the period of production and the body is wet and the sex is poor.

项目成果

The association between dioxins and steroid hormones in general adult males: a cross-sectional study in an e-waste region of China

• DOI: 10.1007/s11356-020-09086-4
• 发表时间: 2020-05
• 期刊: Environmental Science and Pollution Research
• 影响因子: 5.8
• 作者: L. Shi;Mei Qin Wang;S. Nakayama;Chau-Ren Jung;Yue Hua Wang;Jingjian Dong;Chaochen Ma;T. Kido