非天然型アミノ酸生産のためのPLP依存性アミノ基転移酵素の改変

“液体相位分离的无膜滴的产生/产生具有新颖特性的能力，使其能够相对于酶有效、高蛋白质卷曲（mM蛋白质含量），以研究详细说明蛋白质和具体地卷曲对酶活性的影响（使用生命系统的长度尺度作为细胞）。”我们也演示了在细胞中爬行生成流的存在中的酶活性是如何与细胞等离子体流的。本作品已由《自然通讯》出版，它是2021年前25名下载量最大的化学和材料科学文章，在《自然通讯》出版。在补充中，我们已经发现蛋白质如何塑造其功能和健康。这项工作已在蛋白质科学中发表。

・The production/generation of liquid-liquid phase separated membrane-less droplets with novel features as the ability to compartmentalize enzymes efficiently, high protein crowding (mM protein content) to study in detail the effects of crowding on proteins and especially on the enzymatic activity (using length scale of living systems micrometer scale as cells).・We also demonstrated how the enzymatic activity in presence of crowding generated flow similar to the cytoplasmatic streaming of the cell. This work has been published by Nature Communications it is amongst the 2021 top 25 most downloaded Chemistry and Material Science Articles in 2021 published in Nature communication.・In addition, we have discovered how protein plasticity shape the function and fitness. The work has been published in Protein Science.